{"product_id":"inje-k-1mg-inj-0-5ml","title":"INJE K 1MG INJ","description":"\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eInjek Phytomenadione Injection is a standout product in our VETERINARY EMERGENCY \u0026amp; ANTIDOTE MEDICINE category. Manufactured by Neon Laboratories Ltd. a trusted and established Indian pharmaceutical company headquartered in Andheri, Mumbai Injek delivers Phytomenadione (Vitamin K1) the naturally occurring, biologically active form of Vitamin K in a sterile, ready-to-use parenteral formulation. Phytomenadione is not merely a nutritional supplement it is the pharmacologically active cofactor for the hepatic enzyme that carboxylates the glutamic acid residues on the inactive precursors of blood coagulation Factors II (Prothrombin), VII (Proconvertin), IX (Christmas Factor), and X (Stuart Factor) the gamma-carboxylation reaction that is absolutely essential for converting these inactive clotting factor precursors into their biologically active, calcium-binding forms capable of participating in the blood coagulation cascade. Anticoagulant rodenticides including warfarin, brodifacoum, bromadiolone, diphacinone, and chlorophacinone are specifically designed to inhibit this critical Vitamin K-dependent gamma-carboxylation step, causing progressive depletion of active clotting factors and the development of life-threatening, spontaneous haemorrhage in animals that ingest them. In India where anticoagulant rodenticide baits are used extensively in homes, kitchens, restaurants, and agricultural settings accidental ingestion by curious, free-roaming, and food-motivated dogs and cats represents one of the most common causes of emergency veterinary presentation, and Phytomenadione injection is the only specific antidote that reverses this life-threatening toxicity by restoring Vitamin K-dependent clotting factor synthesis. With Injek, veterinarians can trust that they are administering pharmaceutical-grade, precisely dosed, and reliably bioavailable Vitamin K1 at the most critical moment of their animal patient's life.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eComposition:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul class=\"[li_\u0026amp;]:mb-0 [li_\u0026amp;]:mt-1 [li_\u0026amp;]:gap-1 [\u0026amp;:not(:last-child)_ul]:pb-1 [\u0026amp;:not(:last-child)_ol]:pb-1 list-disc flex flex-col gap-1 pl-8 mb-3\"\u003e\n\u003cli class=\"whitespace-normal break-words pl-2\"\u003e\n\u003cstrong\u003ePhytomenadione (Vitamin K1) 1mg (Active Ingredient):\u003c\/strong\u003e the naturally occurring, biologically active form of Vitamin K specifically the trans-isomer of 2-methyl-3-phytyl-1,4-naphthoquinone. Phytomenadione is the only form of Vitamin K that is reliably effective for reversing anticoagulant rodenticide toxicosis Vitamin K3 (Menadione\/Menadiol) is ineffective for this indication and Vitamin K2 (Menaquinone) has insufficient activity. The mechanism of Phytomenadione's therapeutic action is its role as the essential cofactor for Vitamin K epoxide reductase (VKOR) the enzyme that cycles Vitamin K between its active hydroquinone (KH2) form and its oxidised epoxide (KO) form. This cycling is essential because the active KH2 form is consumed as the gamma-carboxylation cofactor in clotting factor synthesis, and must be continuously regenerated by VKOR for hepatic clotting factor production to continue. Anticoagulant rodenticides (coumarins and indandiones) are potent, highly selective inhibitors of VKOR they bind and block this enzyme, preventing Vitamin K recycling, depleting the active KH2 pool, and consequently blocking the gamma-carboxylation of clotting factor precursors. The liver then accumulates inactive clotting factor precursors (PIVKAs Proteins Induced by Vitamin K Absence or Antagonism) that cannot participate in the coagulation cascade, resulting in progressive coagulopathy. Administering exogenous Phytomenadione bypasses the blocked VKOR pathway the pharmaceutical KH2 is directly available as the gamma-carboxylation cofactor, restoring clotting factor synthesis and reversing the coagulopathy within 1 to 2 hours of administration. For long-acting second-generation rodenticides (brodifacoum, bromadiolone) which bind VKOR with very high affinity and have long tissue half-lives of weeks to months extended, continuous Phytomenadione therapy of 4 to 6 weeks is required to maintain adequate Vitamin K availability throughout the rodenticide's persistence in the animal's body\u003c\/li\u003e\n\u003cli class=\"whitespace-normal break-words pl-2\"\u003e\n\u003cstrong\u003ePolyethoxylated Castor Oil \/ Cremophor EL (Solubilising Agent):\u003c\/strong\u003e a pharmaceutical surfactant used to solubilise the lipid-soluble Phytomenadione in the aqueous injection vehicle creating the stable, injectable colloidal solution that allows parenteral delivery of an otherwise water-insoluble compound. Note: Cremophor EL is the component most associated with the rare anaphylactoid reactions that can occur with intravenous Vitamin K1 administration this is the primary pharmacological basis for the strong preference for subcutaneous over intravenous administration of Phytomenadione\u003c\/li\u003e\n\u003cli class=\"whitespace-normal break-words pl-2\"\u003e\n\u003cstrong\u003eDextrose \/ Benzyl Alcohol \/ Sterile Water for Injection (Stabilising Vehicle):\u003c\/strong\u003e pharmaceutical-grade vehicle components maintaining chemical stability, isotonicity, and microbiological integrity of the parenteral formulation throughout its shelf life\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"NEON","offers":[{"title":"0.5mL","offer_id":42342058721341,"sku":"2847","price":29.0,"currency_code":"INR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0586\/7883\/7309\/files\/INJE-K-1MG-INJ-Animeal-27237856444477.png?v=1775529590","url":"https:\/\/animeal.in\/products\/inje-k-1mg-inj-0-5ml","provider":"Animeal","version":"1.0","type":"link"}