{"product_id":"pipzo-1-125-inj-1pc","title":"PIPZO 1.125 INJ","description":"\u003cdiv\u003e\n\u003cdiv class=\"standard-markdown grid-cols-1 grid [\u0026amp;_\u0026gt;_*]:min-w-0 gap-3\"\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003ePipzo Piperacillin and Tazobactam Injection 1.125g, manufactured by Alkem Laboratories Ltd., is a cutting-edge, hospital-grade, broad-spectrum combination antibiotic formulated to address moderate to severe bacterial infections that have proven resistant or difficult to manage with single-agent therapy. The core clinical challenge this product targets is bacterial resistance, specifically the ability of many gram-negative and gram-positive pathogens to produce beta-lactamase enzymes that destroy conventional penicillin-class antibiotics before they can exert their bactericidal action. Pipzo 1.125g resolves this resistance mechanism by pairing a potent anti-pseudomonal penicillin with a clinically proven beta-lactamase inhibitor, restoring and amplifying antibiotic efficacy against a wide spectrum of difficult-to-treat organisms. This injection is administered exclusively in hospital and clinical settings under the direct supervision of a qualified medical professional. Animeal is proud to offer Pipzo Piperacillin and Tazobactam Injection 1.125g as part of our commitment to providing veterinary and medical professionals with access to clinically validated, pharmaceutical-grade therapeutic products that protect the health of patients across species.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv\u003e\n\u003cdiv class=\"standard-markdown grid-cols-1 grid [\u0026amp;_\u0026gt;_*]:min-w-0 gap-3\"\u003e\n\u003ch3 class=\"text-text-100 mt-3 -mb-1 text-[1.125rem] font-bold\"\u003e\u003cstrong\u003eIngredients:\u003c\/strong\u003e\u003c\/h3\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv\u003e\n\u003cdiv class=\"standard-markdown grid-cols-1 grid [\u0026amp;_\u0026gt;_*]:min-w-0 gap-3\"\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003ePiperacillin Sodium 1000mg (equivalent to Piperacillin 1g):\u003c\/strong\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv\u003e\n\u003cdiv class=\"standard-markdown grid-cols-1 grid [\u0026amp;_\u0026gt;_*]:min-w-0 gap-3\"\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003ePiperacillin is an extended-spectrum ureidopenicillin antibiotic that operates by irreversibly inhibiting transpeptidase enzymes, specifically penicillin-binding proteins (PBPs) located on the inner membrane of bacterial cell walls. These PBPs are responsible for catalysing the final cross-linking step in peptidoglycan synthesis, the structural polymer that maintains bacterial cell wall integrity. By binding to and inactivating PBPs, Piperacillin prevents the formation of this critical scaffold, rendering the bacterial cell wall structurally unstable. The resulting osmotic imbalance causes cellular lysis and bacterial death. Piperacillin demonstrates broad activity against gram-positive organisms including Streptococcus spp. and Staphylococcus spp. (non-beta-lactamase-producing strains), and crucially against gram-negative bacteria including Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, and Haemophilus influenzae. Its anti-pseudomonal activity distinguishes it from narrower penicillins, making it indispensable in the management of nosocomial and polymicrobial infections.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv\u003e\n\u003cdiv class=\"standard-markdown grid-cols-1 grid [\u0026amp;_\u0026gt;_*]:min-w-0 gap-3\"\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eTazobactam Sodium 125mg (equivalent to Tazobactam 0.125g):\u003c\/strong\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv\u003e\n\u003cdiv class=\"standard-markdown grid-cols-1 grid [\u0026amp;_\u0026gt;_*]:min-w-0 gap-3\"\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eTazobactam is a triazolylmethyl penicillanic acid sulfone and a potent, irreversible beta-lactamase inhibitor. Many bacteria have evolved the capacity to produce beta-lactamase enzymes, which hydrolyse and inactivate the beta-lactam ring of penicillin-class antibiotics, rendering them therapeutically ineffective. Tazobactam functions as a suicide substrate: it binds with high affinity to beta-lactamase enzymes, forming a stable acyl-enzyme complex that permanently inactivates the enzyme before it can degrade Piperacillin. This mechanism, known as mechanism-based inhibition, is effective against a broad range of beta-lactamases including TEM, SHV, and OXA types produced by gram-negative organisms. By neutralising resistance at the enzymatic level, Tazobactam dramatically extends the spectrum and potency of Piperacillin, allowing it to act against beta-lactamase-producing strains that would otherwise be fully resistant.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e","brand":"ALKEM","offers":[{"title":"1Pc","offer_id":42344644640829,"sku":"6951","price":111.62,"currency_code":"INR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0586\/7883\/7309\/files\/PIPZO-1-125-INJ-Animeal-27325938532413.png?v=1777772921","url":"https:\/\/animeal.in\/products\/pipzo-1-125-inj-1pc","provider":"Animeal","version":"1.0","type":"link"}