Calm ear drops is a Ofloxacin + Beclometasone ear drop, used to treat ear infections. CalmEar Ofloxacin ear drops are a prescription antibacterial solution that stops bacterial ear infections and give dogs and cats quick relief from pain, swelling, itching, and discomfort. Ofloxacin is a quinolone antibiotic that inhibits bacterial "dna gyrase", an enzyme required for the replication, transcription and repair of the dna.