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INJECTABLE
BENTHIPEN 3P L.A INJ
BENTHIPEN 3P L.A INJ
By CAREVET PHARMA
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About Product
BENTHIPEN 3P L.A. Injection by CareVet Pharma is a pioneering, long-acting triple penicillin formulation developed for the treatment of moderate to severe systemic bacterial infections in livestock. It directly addresses one of the most persistent challenges in large animal veterinary medicine the need for a broad-spectrum, sustained-release antibiotic that delivers both a rapid bactericidal response at the onset of infection and prolonged therapeutic blood levels sufficient to eliminate the pathogen without requiring frequent repeat dosing. Standard single penicillin formulations either act too briefly for comprehensive infection clearance or too slowly to arrest the initial bacterial proliferation. BENTHIPEN 3P L.A. resolves this limitation by uniquely combining three distinct pharmacokinetic profiles of Penicillin G within a single vial providing immediate, intermediate, and long-lasting antibacterial action in a single deep intramuscular administration. Indicated primarily for cattle, buffalo, and other large livestock animals, this Schedule H veterinary prescription product is manufactured by CareVet Pharma, one of India's most trusted names in veterinary pharmaceuticals. Animeal is proud to offer BENTHIPEN 3P L.A. Injection as part of our comprehensive range of veterinary pharmaceutical solutions for the health and wellbeing of your farm animals.
Ingredients:
Penicillin G Sodium (Benzylpenicillin Sodium): Penicillin G Sodium is the highly water-soluble, rapidly absorbed crystalline salt of benzylpenicillin. Following deep intramuscular injection, it dissociates rapidly and is absorbed into systemic circulation within minutes, producing an immediate and potent bactericidal spike in plasma penicillin concentration. At the molecular level, Penicillin G Sodium in common with all beta-lactam antibiotics exerts its bactericidal action by irreversibly binding to Penicillin-Binding Proteins (PBPs), specifically transpeptidase enzymes located on the inner surface of the bacterial cell membrane. This binding inhibits the cross-linking of peptidoglycan strands that form the structural backbone of the bacterial cell wall. With peptidoglycan synthesis arrested during active bacterial multiplication, the cell wall becomes osmotically unstable, leading to autolytic lysis and rapid bacterial cellular death. Penicillin G Sodium ensures that the critical earliest phase of infection when bacterial burden is rising most rapidly is met with an immediate and forceful bactericidal response. Its plasma half-life following intramuscular administration is approximately 1 to 2 hours in large animals.
Penicillin G Procaine (Procaine Benzylpenicillin): Penicillin G Procaine is a complex formed by the equimolecular combination of benzylpenicillin and procaine hydrochloride. Procaine, a local anaesthetic agent, reduces the solubility of Penicillin G at the injection depot site, slowing its rate of absorption from the intramuscular tissue into systemic circulation. This controlled-release depot effect extends the plasma half-life of benzylpenicillin to approximately 20 to 24 hours following a single intramuscular dose, bridging the gap between the rapid initial peak delivered by Penicillin G Sodium and the prolonged coverage provided by Penicillin G Benzathine. Penicillin G Procaine carries the identical antibacterial mechanism of action as all beta-lactam agents PBP binding and peptidoglycan transpeptidase inhibition resulting in cell wall lysis of actively dividing susceptible bacteria. Its intermediate pharmacokinetic profile ensures that therapeutic plasma concentrations above the minimum inhibitory concentration (MIC) are maintained throughout the critical 12 to 24 hour post-injection window, preventing bacterial regrowth after the Penicillin G Sodium peak has subsided.
Penicillin G Benzathine (Benzathine Benzylpenicillin): Penicillin G Benzathine is the most water-insoluble and slowest-releasing of the three penicillin salts, formed by combining two molecules of benzylpenicillin with one molecule of N,N'-dibenzylethylenediamine. This extreme insolubility creates a highly stable intramuscular depot that releases penicillin G into systemic circulation very slowly over an extended period of 48 to 72 hours or more, sustaining antibacterial plasma concentrations long after the Procaine salt's coverage has diminished. The antibacterial mechanism is identical to that of the other Penicillin G forms irreversible binding to PBPs, inhibition of peptidoglycan transpeptidation, and osmotic destabilization leading to bacterial cell wall lysis. The unique value of Penicillin G Benzathine lies in its pharmacokinetic contribution: by maintaining therapeutic blood levels across the extended post-injection period, it reinforces the complete bacterial eradication of slow-multiplying or deep-tissue pathogens that require sustained antibiotic pressure for elimination.
Features and Benefits
Trimodal Pharmacokinetic Design for Comprehensi...
Trimodal Pharmacokinetic Design for Comprehensive Infection Control:
The defining therapeutic advantage of BENTHIPEN 3P L.A. is its engineered trimodal plasma concentration profile. Penicillin G Sodium delivers a rapid bactericidal peak within minutes of injection, Penicillin G Procaine sustains intermediate therapeutic levels across the following 20 to 24 hours, and Penicillin G Benzathine extends coverage for up to 72 hours or more. This uninterrupted antibacterial coverage across all three pharmacokinetic phases ensures that the infecting bacterial population is targeted continuously from the moment of injection through to the extended post-treatment period, dramatically reducing the risk of bacterial regrowth between doses.
Long-Acting Formulation Reduces Dosing Frequency:
The long-acting architecture of BENTHIPEN 3P L.A. driven primarily by the sustained-release Penicillin G Benzathine depot significantly reduces the number of injections required to achieve a complete treatment course when compared to short-acting penicillin formulations. For livestock managers and veterinary professionals working with large numbers of animals, reduced dosing frequency means less handling-related stress for the animals and greater treatment compliance across the herd, both of which are clinically associated with improved treatment outcomes.
Broad-Spectrum Efficacy Against Key Livestock Pathogens:
The triple-salt penicillin formulation targets a clinically relevant spectrum of penicillin-susceptible pathogens that are responsible for the most economically significant infections in large livestock, including Streptococcus spp., penicillinase-negative Staphylococcus spp., Clostridium spp., Pasteurella spp., Corynebacterium spp., Erysipelothrix spp., Listeria spp., and Haemophilus spp. This breadth of coverage makes BENTHIPEN 3P L.A. an effective first-line treatment choice for respiratory, gastrointestinal, urinary, mastitis, and soft tissue infections in livestock, even before full laboratory sensitivity confirmation is available.
Pioneering Veterinary Formulation Made in India:
BENTHIPEN 3P L.A. represents a landmark achievement in Indian veterinary pharmaceutical innovation bringing a sophisticated triple-salt long-acting penicillin formulation to domestic livestock producers at accessible pricing. Manufactured under the rigorous quality control standards of CareVet Pharma and classified as a Schedule H prescription veterinary medicine, it meets the standards expected of a professional-grade injectable antibiotic in livestock clinical practice.
Convenient Large-Animal Dosing with Single-Vial Sufficiency:
Each vial of BENTHIPEN 3P L.A. at 48 Lac IU provides sufficient dose to treat up to 400 kg body weight at the recommended dosage of 10,000 IU per kg, making it ideally suited to the body weight demands of large livestock animals such as adult cattle and buffalo. The simple reconstitution protocol dispersal in 20 ml of sterile water for injection allows for rapid preparation under field conditions.
Usage and Applications
How to Use:BENTHIPEN 3P L.A. Injection is a Sch...
How to Use:
BENTHIPEN 3P L.A. Injection is a Schedule H prescription veterinary medicine. It must only be prescribed, prepared, and administered by or under the direct supervision of a registered veterinary surgeon. Do not attempt to self-administer this product without veterinary guidance.
Storage Advice:
Store unopened BENTHIPEN 3P L.A. Injection vials in a cool, dry place below 25 degrees Celsius, away from direct sunlight and sources of heat or moisture. Do not freeze. Once reconstituted with sterile water for injection, the suspension should be used immediately and any remainder discarded reconstituted product should not be stored for future use. Store in accordance with applicable Schedule H controlled veterinary medicine storage requirements, keeping this product secure and accessible only to authorized veterinary personnel. Do not use after the best-before or expiry date printed on the vial label and outer packaging.
About the Brand:
Established in 1989 in Ludhiana, Punjab, CareVet Pharma is one of India's most longstanding and respected wholesale traders and marketers of veterinary pharmaceutical products, with over three and a half decades of dedicated service to the country's animal healthcare professionals and livestock industry. Operating to the highest standards of business ethics, CareVet Pharma subjects every product in its portfolio spanning veterinary injections, feed supplements, and veterinary boluses to stringent quality control evaluation and field-based testing conducted by qualified veterinary professionals before release to the market. The company's product philosophy is firmly rooted in the belief that animal health solutions must combine clinical efficacy with practical field utility, a standard exemplified by the innovative triple-penicillin formulation of BENTHIPEN 3P L.A. With a continuously expanding nationwide distribution network driven by a well-trained dedicated field force and strong partnerships with veterinary professionals across the country, CareVet Pharma's commitment to quality, excellence, and accessible animal healthcare aligns with Animeal's commitment to offering only the most trusted veterinary-grade products to Indian pet and livestock owners. Discover CareVet Pharma today.
Disclaimer:
Please note that BENTHIPEN 3P L.A. Injection is formulated from Penicillin G Benzathine, Penicillin G Procaine, and Penicillin G Sodium, and is appropriate for large livestock animals including cattle and buffalo under veterinary prescription and supervision. It is a Schedule H prescription-only veterinary pharmaceutical and must not be purchased, stored, or administered without a valid prescription from a registered veterinary surgeon. This product is not for use in companion animals such as dogs and cats without specific veterinary guidance, and is strictly contraindicated in guinea pigs, chinchillas, rabbits, birds, snakes, and turtles. For animals with a known history of hypersensitivity to penicillin or procaine, this product is absolutely contraindicated consult your veterinarian before introducing this product to any animal with a history of antibiotic reactions or pre-existing renal or neurological conditions. Animeal supports your animal's health and happiness journey but does not replace the advice of a qualified veterinary professional.
