BENTHIPEN 3P L.A INJ
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BENTHIPEN 3P L.A. Injection by CareVet Pharma is a pioneering, long-acting triple penicillin formulation developed for the treatment of moderate to severe systemic bacterial infections in livestock. It directly addresses one of the most persistent challenges in large animal veterinary medicine the need for a broad-spectrum, sustained-release antibiotic that delivers both a rapid bactericidal response at the onset of infection and prolonged therapeutic blood levels sufficient to eliminate the pathogen without requiring frequent repeat dosing. Standard single penicillin formulations either act too briefly for comprehensive infection clearance or too slowly to arrest the initial bacterial proliferation. BENTHIPEN 3P L.A. resolves this limitation by uniquely combining three distinct pharmacokinetic profiles of Penicillin G within a single vial providing immediate, intermediate, and long-lasting antibacterial action in a single deep intramuscular administration. Indicated primarily for cattle, buffalo, and other large livestock animals, this Schedule H veterinary prescription product is manufactured by CareVet Pharma, one of India's most trusted names in veterinary pharmaceuticals. Animeal is proud to offer BENTHIPEN 3P L.A. Injection as part of our comprehensive range of veterinary pharmaceutical solutions for the health and wellbeing of your farm animals.
Ingredients:
Penicillin G Sodium (Benzylpenicillin Sodium): Penicillin G Sodium is the highly water-soluble, rapidly absorbed crystalline salt of benzylpenicillin. Following deep intramuscular injection, it dissociates rapidly and is absorbed into systemic circulation within minutes, producing an immediate and potent bactericidal spike in plasma penicillin concentration. At the molecular level, Penicillin G Sodium in common with all beta-lactam antibiotics exerts its bactericidal action by irreversibly binding to Penicillin-Binding Proteins (PBPs), specifically transpeptidase enzymes located on the inner surface of the bacterial cell membrane. This binding inhibits the cross-linking of peptidoglycan strands that form the structural backbone of the bacterial cell wall. With peptidoglycan synthesis arrested during active bacterial multiplication, the cell wall becomes osmotically unstable, leading to autolytic lysis and rapid bacterial cellular death. Penicillin G Sodium ensures that the critical earliest phase of infection when bacterial burden is rising most rapidly is met with an immediate and forceful bactericidal response. Its plasma half-life following intramuscular administration is approximately 1 to 2 hours in large animals.
Penicillin G Procaine (Procaine Benzylpenicillin): Penicillin G Procaine is a complex formed by the equimolecular combination of benzylpenicillin and procaine hydrochloride. Procaine, a local anaesthetic agent, reduces the solubility of Penicillin G at the injection depot site, slowing its rate of absorption from the intramuscular tissue into systemic circulation. This controlled-release depot effect extends the plasma half-life of benzylpenicillin to approximately 20 to 24 hours following a single intramuscular dose, bridging the gap between the rapid initial peak delivered by Penicillin G Sodium and the prolonged coverage provided by Penicillin G Benzathine. Penicillin G Procaine carries the identical antibacterial mechanism of action as all beta-lactam agents PBP binding and peptidoglycan transpeptidase inhibition resulting in cell wall lysis of actively dividing susceptible bacteria. Its intermediate pharmacokinetic profile ensures that therapeutic plasma concentrations above the minimum inhibitory concentration (MIC) are maintained throughout the critical 12 to 24 hour post-injection window, preventing bacterial regrowth after the Penicillin G Sodium peak has subsided.
Penicillin G Benzathine (Benzathine Benzylpenicillin): Penicillin G Benzathine is the most water-insoluble and slowest-releasing of the three penicillin salts, formed by combining two molecules of benzylpenicillin with one molecule of N,N'-dibenzylethylenediamine. This extreme insolubility creates a highly stable intramuscular depot that releases penicillin G into systemic circulation very slowly over an extended period of 48 to 72 hours or more, sustaining antibacterial plasma concentrations long after the Procaine salt's coverage has diminished. The antibacterial mechanism is identical to that of the other Penicillin G forms irreversible binding to PBPs, inhibition of peptidoglycan transpeptidation, and osmotic destabilization leading to bacterial cell wall lysis. The unique value of Penicillin G Benzathine lies in its pharmacokinetic contribution: by maintaining therapeutic blood levels across the extended post-injection period, it reinforces the complete bacterial eradication of slow-multiplying or deep-tissue pathogens that require sustained antibiotic pressure for elimination.
