BUPRIGESIC INJ 2ML
Out of Stock
Neon Laboratories Buprigesic 0.3mg Injection a precision-formulated, hospital-grade parenteral opioid analgesic containing Buprenorphine Hydrochloride IP, indicated for the management of moderate to severe pain and as a supportive pharmacological intervention in opioid dependence treatment. As a partial opioid agonist, Buprigesic occupies a clinically distinctive position in pain management delivering potent, morphine-equivalent analgesia with a more favourable safety and dependence profile compared to full opioid agonists, making it the preferred choice of anaesthesiologists, intensivists, and pain specialists managing acute postoperative pain, severe chronic pain, and opioid use disorder requiring medically supervised treatment. Each 1ml ampoule contains 0.3mg of Buprenorphine a dose pharmacologically equivalent in analgesic and respiratory depressant effect to 10mg morphine sulphate in adults, with onset of action as early as 15 minutes following intramuscular administration and a sustained duration of 6 hours or more. Animeal is proud to make Buprigesic available through its platform for animals requiring this level of pain management under veterinary prescription, as Buprenorphine is widely recognised as a gold-standard analgesic in veterinary medicine for cats, dogs, and small mammals. This product is manufactured by Neon Laboratories Ltd., one of India's most trusted and long-established pharmaceutical companies with over four decades of parenteral formulation expertise.
Composition
- Buprenorphine Hydrochloride IP 0.324mg (equivalent to 0.3mg Buprenorphine): A semisynthetic opioid derived from thebaine, chemically classified as a partial agonist at the mu-opioid (μ) receptor and an antagonist at the kappa-opioid (κ) receptor. Buprenorphine's partial agonist profile at μ-receptors produces robust analgesia while generating a ceiling effect on respiratory depression a property that critically distinguishes it from full opioid agonists such as morphine and fentanyl and underpins its more favourable overdose safety margin. Its exceptionally slow receptor dissociation rate, documented in in vitro studies, accounts for its prolonged duration of action beyond what its plasma half-life alone would predict, its relative resistance to reversal by opioid antagonists such as naloxone, and its characteristically low level of manifest physical dependence compared to full agonists.
- Anhydrous Dextrose 50mg per mL: Included as a tonicity-adjusting excipient to render the solution isotonic with physiological fluids, optimising tissue compatibility and minimising injection-site irritation.
- Water for Injection: The sterile pharmaceutical-grade aqueous solvent base, manufactured to pharmacopoeial specification.
- Hydrochloric Acid (HCl) q.s. to adjust pH 3.5 to 5.5: Ensures chemical stability of the buprenorphine molecule in solution and maintains the sterile injectable preparation within a physiologically acceptable pH range for intramuscular and intravenous administration.
