INJECTABLE

BUPRIGESIC INJ 2ML

BUPRIGESIC INJ 2ML

By NEON

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Pack - 2mL
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About Product

 

Neon Laboratories Buprigesic 0.3mg Injection a precision-formulated, hospital-grade parenteral opioid analgesic containing Buprenorphine Hydrochloride IP, indicated for the management of moderate to severe pain and as a supportive pharmacological intervention in opioid dependence treatment. As a partial opioid agonist, Buprigesic occupies a clinically distinctive position in pain management delivering potent, morphine-equivalent analgesia with a more favourable safety and dependence profile compared to full opioid agonists, making it the preferred choice of anaesthesiologists, intensivists, and pain specialists managing acute postoperative pain, severe chronic pain, and opioid use disorder requiring medically supervised treatment. Each 1ml ampoule contains 0.3mg of Buprenorphine a dose pharmacologically equivalent in analgesic and respiratory depressant effect to 10mg morphine sulphate in adults, with onset of action as early as 15 minutes following intramuscular administration and a sustained duration of 6 hours or more. Animeal is proud to make Buprigesic available through its platform for animals requiring this level of pain management under veterinary prescription, as Buprenorphine is widely recognised as a gold-standard analgesic in veterinary medicine for cats, dogs, and small mammals. This product is manufactured by Neon Laboratories Ltd., one of India's most trusted and long-established pharmaceutical companies with over four decades of parenteral formulation expertise.

Composition

  • Buprenorphine Hydrochloride IP 0.324mg (equivalent to 0.3mg Buprenorphine): A semisynthetic opioid derived from thebaine, chemically classified as a partial agonist at the mu-opioid (μ) receptor and an antagonist at the kappa-opioid (κ) receptor. Buprenorphine's partial agonist profile at μ-receptors produces robust analgesia while generating a ceiling effect on respiratory depression a property that critically distinguishes it from full opioid agonists such as morphine and fentanyl and underpins its more favourable overdose safety margin. Its exceptionally slow receptor dissociation rate, documented in in vitro studies, accounts for its prolonged duration of action beyond what its plasma half-life alone would predict, its relative resistance to reversal by opioid antagonists such as naloxone, and its characteristically low level of manifest physical dependence compared to full agonists.
  • Anhydrous Dextrose 50mg per mL: Included as a tonicity-adjusting excipient to render the solution isotonic with physiological fluids, optimising tissue compatibility and minimising injection-site irritation.
  • Water for Injection: The sterile pharmaceutical-grade aqueous solvent base, manufactured to pharmacopoeial specification.
  • Hydrochloric Acid (HCl) q.s. to adjust pH 3.5 to 5.5: Ensures chemical stability of the buprenorphine molecule in solution and maintains the sterile injectable preparation within a physiologically acceptable pH range for intramuscular and intravenous administration.

Features and Benefits

Morphine-Equivalent Analgesia with Superior Saf...

Morphine-Equivalent Analgesia with Superior Safety Profile: At 0.3mg, Buprigesic delivers analgesia pharmacologically equivalent to 10mg morphine sulphate in adults, while the ceiling effect on respiratory depression at higher doses provides a clinically meaningful safety advantage over full mu-agonists in both human and veterinary applications.

Rapid Onset, Sustained Duration: Pharmacological effects commence within 15 minutes of intramuscular injection, with peak effects at approximately 1 hour and duration extending to 6 hours or longer reducing dosing frequency in clinical pain management settings.

Partial Agonist Lower Dependence Liability: Buprenorphine's partial agonism and characteristically slow receptor dissociation produce significantly lower manifest physical dependence compared to full opioid agonists, making it clinically advantageous for both pain management and dependence treatment.

Dual-Route Administration: Suitable for both deep intramuscular and slow intravenous administration, providing flexible delivery options across clinical and veterinary settings.

Opioid Dependence Management: Beyond analgesia, Buprigesic's partial agonist properties make it a pharmacologically rational intervention in opioid use disorder, reducing withdrawal severity and cravings while blocking the reinforcing effects of illicit opioid use.

Sterile, Precisely Dosed Ampoule Presentation: Available in sealed 1ml ampoules containing exactly 0.3mg Buprenorphine ensuring accurate, consistent dosing with each administration.

WHO-GMP Manufactured: Produced by Neon Laboratories Ltd. across manufacturing facilities compliant with World Health Organization Good Manufacturing Practice standards ensuring batch-to-batch consistency, sterility assurance, and pharmaceutical-grade quality throughout.

Usage and Applications

How to Use:Buprigesic 0.3mg Injection must be a...

How to Use:

Buprigesic 0.3mg Injection must be administered by or under the direct supervision of a qualified medical or veterinary professional. It must not be self-administered. Inspect the ampoule visually for particulate matter or discolouration before use; do not administer if either is observed.

The dose, frequency, and duration of treatment must always be individually determined by the prescribing physician or veterinarian based on the patient's condition, weight, response to treatment, concurrent medications, and overall health status. Do not stop or alter the dosing schedule without professional guidance, as abrupt discontinuation may precipitate withdrawal symptoms in patients on regular therapy.

Storage Advice:

Store Buprigesic 0.3mg Injection ampoules in a cool, dry place below 25°C, away from direct sunlight and heat sources. Do not freeze. Handle ampoules with care to prevent breakage. Once opened, the entire contents of the ampoule must be used immediately partial-use ampoules must not be stored or reused, as this is a single-dose sterile unit. As a Schedule H / controlled substance, Buprigesic must be stored securely in accordance with applicable narcotics and controlled substances regulations under the Narcotic Drugs and Psychotropic Substances (NDPS) Act, 1985. Keep out of reach of children. Do not use after the expiry date printed on the ampoule and outer carton.

About Neon Laboratories Ltd:

Neon Laboratories Ltd. is one of India's most respected and long-established pharmaceutical companies, incorporated in Mumbai in 1982 under the leadership of the Jain family and promoted by Mr. B.K. Jain, Chairman and Managing Director. Launching its first anaesthetic product in 1984, Neon rapidly grew from a focused parenteral anaesthesia manufacturer into a fully diversified pharmaceutical group with recognised leadership in anaesthesiology, critical care, pain management, oncology, cardiology, and gynaecology. With three WHO-GMP compliant manufacturing facilities including a primary facility at Palghar, Maharashtra Neon operates with an uncompromising commitment to Total Quality Management, manufacturing over 40 parenteral molecules with a basket of products that spans Active Pharmaceutical Ingredients, injectable formulations, transdermal delivery systems, and oral solid dosage forms. Holding more than 14 Indian and global patents and serving markets across India, the Middle East, Central America, and South America, Neon's four-decade track record of pharmaceutical innovation, quality-first culture, and rigorous regulatory compliance aligns deeply with Animeal's commitment to bringing only the most clinically credible and trusted products to India's pet parents and veterinary community. Discover Neon Laboratories today.

Disclaimer:

Please note that Buprigesic 0.3mg Injection (Buprenorphine Hydrochloride IP) is a Schedule H prescription-only pharmaceutical and a controlled substance regulated under the Narcotic Drugs and Psychotropic Substances (NDPS) Act, 1985. This product must not be purchased, possessed, or administered without a valid prescription issued by a registered medical practitioner or veterinarian. It must under no circumstances be self-administered by a patient or pet owner outside of a clinical or supervised veterinary setting. Buprenorphine carries a risk of opioid dependence, abuse, and misuse, which can lead to overdose and death if used outside of medically supervised protocols. The product information provided on this page is intended strictly for educational and informational reference purposes and does not constitute medical advice, veterinary advice, a diagnosis, or a treatment recommendation. All dosage, administration, and treatment decisions must be made exclusively by a qualified physician or veterinarian following individual clinical assessment. For animals, this product should only be administered by or under the direct supervision of a licensed veterinarian. Animeal supports your pet's health and wellbeing but does not replace the expertise or clinical judgement of a qualified veterinary professional.

Frequently Asked Questions

Is Buprigesic 0.3mg Injection suitable for use in companion animals such as dogs and cats?

Yes. Buprenorphine is one of the most widely used and well-evidenced opioid analgesics in veterinary medicine, particularly in cats and dogs, where it is valued for its reliable analgesia, wide therapeutic margin, and favourable partial agonist safety profile. However, it is a controlled substance and must be prescribed and administered exclusively by a licensed veterinarian. It is not available for home administration by pet owners without professional supervision.

How frequently can Buprigesic be administered, and how long does each dose last?

In adult humans, the standard dosing interval is up to every 6 hours as needed. In veterinary patients, dosing is typically every 4 to 8 hours depending on species, body weight, clinical indication, and the treating veterinarian's assessment. The onset of analgesia occurs within 15 minutes of intramuscular injection, with peak effect at approximately 1 hour and duration extending to 6 hours or longer.

How does Buprigesic differ from morphine or other opioid injections?

Unlike full opioid agonists such as morphine, Buprigesic contains Buprenorphine a partial mu-opioid receptor agonist which produces morphine-equivalent analgesia at therapeutic doses but exhibits a ceiling effect on respiratory depression at higher doses, resulting in a more favourable overdose safety margin. Its characteristically slow receptor dissociation also results in a longer duration of action and lower manifest physical dependence compared to full agonists, making it preferable in certain clinical and veterinary pain management

What are the potential side effects I should monitor for?

Common side effects include sedation or drowsiness, nausea, vomiting, dizziness, headache, and decreased respiratory rate. In animals, signs to monitor include excessive sedation, slow or laboured breathing, disorientation, and vomiting. Serious adverse effects include respiratory depression and CNS depression, which are more likely with concurrent use of other sedatives, benzodiazepines, or alcohol. If any concerning signs are observed following administration, contact your physician or veterinarian immediately.

How can I purchase Buprigesic 0.3mg Injection through Animeal?

As Buprigesic is a Schedule H controlled substance, a valid prescription from a registered medical practitioner or licensed veterinarian is mandatory for purchase. You can place your order through the Animeal website or app and our pharmacy team will guide you through the prescription verification process in accordance with applicable regulations under the Drugs and Cosmetics Act, 1940 and the NDPS Act, 1985. For institutional or bulk veterinary orders, please contact our customer support team directly.