CALSHAKTI PLATINA (XL)

Calshakti Liquid by Intas Pharmaceuticals Ltd. is a cutting-edge veterinary nutritional oral liquid feed supplement formulated to address one of the most economically and physiologically critical challenges in Indian dairy and livestock farming calcium deficiency and its cascading consequences across bone health, reproductive performance, milk production, and metabolic vitality in large and small ruminants. Calcium is the most abundant mineral in the animal body and the single most demanded nutrient during pregnancy, parturition, peak lactation, and periods of rapid growth making hypocalcaemia and subclinical calcium deficiency the most prevalent nutritional disorders in high-yielding dairy cows, buffaloes, and other livestock across India. The consequences of unaddressed calcium deficiency extend far beyond weakened bones: they include impaired uterine contractility leading to dystocia, retained placenta, and prolapse; dramatically reduced milk yield; poor post-partum recovery; metabolic stress in transition animals; and suppressed immunity leaving animals vulnerable to mastitis and systemic infections. Calshakti Liquid resolves this challenge through a precisely engineered oral liquid formula combining inorganic calcium and phosphorus at clinically significant concentrations with the synergistic support of Vitamin D3, Vitamin B12, and three traditionally validated Ayurvedic herbal extracts Shatavari (Asparagus racemosus), Jivanti (Leptadenia reticulata), and Piper longum delivering a comprehensive, multi-dimensional nutritional intervention that replenishes depleted calcium reserves, stimulates galactogogue activity, and reinforces overall metabolic and reproductive health. Available in a practical 10-litre economy pack ideal for farm and herd use, Calshakti Liquid is manufactured by Intas Animal Health, one of India's top three animal health companies. Animeal is proud to offer Calshakti Liquid as part of our comprehensive range of nutritional solutions for the health and productivity of your livestock.

Ingredients:

Calcium 1700 mg per 100 ml: Calcium is the most abundant and physiologically indispensable mineral in the livestock body, serving as the structural cornerstone of bone and tooth mineralisation while simultaneously performing critical regulatory roles across neuromuscular transmission, smooth and skeletal muscle contractility, cardiac rhythm, blood coagulation, and enzyme activation. At the cellular level, calcium ions act as the primary intracellular second messenger in numerous signalling cascades including those governing uterine smooth muscle contraction during parturition and the myoepithelial cell contraction in mammary alveoli that drives milk let-down. In high-yielding dairy cows and buffaloes, the transition from late pregnancy to peak lactation demands a dramatic increase in calcium mobilisation from approximately 10 g per day in late gestation to 30 g or more per day at peak milk yield a demand that frequently outpaces the animal's endogenous calcium absorption and bone resorption capacity, precipitating clinical or subclinical hypocalcaemia. Calshakti Liquid delivers 1700 mg of calcium per 100 ml in a readily bioavailable liquid form for immediate gastrointestinal absorption, rapidly replenishing circulating plasma calcium and restoring the ionic calcium pool essential for normal neuromuscular function, milk production, and reproductive contractility.

Phosphorus 850 mg per 100 ml: Phosphorus is delivered in a precisely calibrated 2:1 ratio with calcium mirroring the physiological calcium-to-phosphorus ratio optimal for bone mineralisation and metabolic function in ruminants. Beyond its structural role in hydroxyapatite crystal formation within bone matrix, phosphorus is the essential component of adenosine triphosphate (ATP) the universal energy currency of every biological process in the animal body. In lactating animals with high energy demands, phosphorus availability directly influences the efficiency of energy metabolism at the cellular level. Phosphorus also forms the backbone of phospholipid bilayers in all cell membranes, supports nucleic acid synthesis (DNA and RNA), and is a key cofactor in the phosphorylation cascades that regulate hormone action and enzyme activity. Deficiency of phosphorus which frequently co-exists with calcium deficiency in transition dairy animals manifests as reduced feed intake, poor reproductive performance, and declining milk yield. The balanced calcium-phosphorus delivery in Calshakti Liquid ensures that supplementation of one mineral does not create a relative deficiency of the other.

Vitamin D3 (Cholecalciferol) 8000 IU per 100 ml: Vitamin D3 (cholecalciferol) is the indispensable regulatory hormone that governs the entire calcium homeostasis system in the animal body. Without adequate Vitamin D3, dietary calcium and phosphorus cannot be efficiently absorbed from the intestine, mobilised from bone reserves, or retained by the kidneys making even high-dose oral calcium supplementation significantly less effective in its absence. Following oral administration, cholecalciferol undergoes hepatic hydroxylation to 25-hydroxyvitamin D3, followed by renal conversion to the active hormonal form 1,25-dihydroxyvitamin D3 (calcitriol). Calcitriol then binds to Vitamin D receptors in intestinal epithelial cells, stimulating the synthesis of calcium-binding proteins (calbindins) that actively transport calcium across the intestinal mucosa into systemic circulation. In the kidney, calcitriol promotes calcium reabsorption in the distal tubule, minimising urinary calcium losses. In bone, it regulates the activity of osteoclasts and osteoblasts, modulating the release of calcium from bone reserves during periods of acute demand. The inclusion of 8000 IU of Vitamin D3 per 100 ml in Calshakti Liquid ensures that the oral calcium and phosphorus delivered by the supplement is bioavailable and actively absorbed, dramatically amplifying the clinical impact of each dose.

Vitamin B12 (Cyanocobalamin) 100 mcg per 100 ml: Vitamin B12 (cyanocobalamin) is an essential water-soluble vitamin that serves as a critical coenzyme in two fundamental metabolic pathways: methylmalonyl-CoA mutase activity which converts propionate to succinate in the citric acid cycle, a pathway of particular importance in ruminants where propionate is the primary gluconeogenic substrate generated from volatile fatty acid fermentation in the rumen and methionine synthase activity, which supports DNA synthesis and normal haematopoiesis (red blood cell formation). In livestock with subclinical cobalt deficiency (which reduces ruminal microbial B12 synthesis), vitamin B12 supplementation directly supports energy metabolism, prevents anaemia, and reinforces the metabolic vitality of transition animals under the physiological stress of parturition and peak lactation. The inclusion of Vitamin B12 in Calshakti Liquid provides a metabolic energy and haematopoietic support layer that complements and amplifies the primary calcium-phosphorus-Vitamin D3 supplementation action.

Extracts of Asparagus racemosus (Shatavari) 1000 mg per 100 ml: Shatavari (Asparagus racemosus) is one of the most thoroughly studied and clinically validated Ayurvedic galactogogue (lactation-promoting) herbs, revered across millennia of traditional Indian veterinary and human medicine for its profound capacity to stimulate and sustain milk production in lactating females. At the pharmacological level, the steroidal saponins of Shatavari including Shatavarin I through IV exert their galactogogue action by stimulating prolactin secretion from the anterior pituitary gland, the primary hormonal driver of mammary gland milk synthesis in all mammals. Elevated prolactin signalling reinforces the secretory activity of mammary alveolar cells, increasing both the volume and quality of milk produced per lactation cycle. Beyond its galactogogue action, Shatavari's phytoestrogenic saponins support uterine health and reproductive cyclicity in post-partum cows and buffaloes, reducing the inter-calving interval and improving overall reproductive efficiency on the farm. Its adaptogenic and immunomodulatory properties also help the transition animal manage the metabolic stress of parturition more effectively.

Extracts of Leptadenia reticulata (Jivanti) 1000 mg per 100 ml: Jivanti (Leptadenia reticulata) is a classical Ayurvedic rejuvenating herb recognised in both Charaka Samhita and Sushruta Samhita for its tonic, galactogogue, and vitalising properties in livestock and humans alike. The bioactive glycosides, steroids, flavonoids, and triterpenoids of Jivanti exert complementary galactogogue and adaptogenic actions alongside Shatavari working synergistically to reinforce prolactin-mediated mammary stimulation while simultaneously strengthening the overall vitality, energy reserves, and reproductive capacity of the supplemented animal. Jivanti's traditional classification as a Jivaniya (life-promoting) herb reflects its broad-spectrum tonic effects on muscular strength, metabolic resilience, and immune competence properties that are particularly valuable for high-yielding dairy animals experiencing the physiological drain of peak lactation. Together, Shatavari and Jivanti form a powerful herbal galactogogue pair at the core of Calshakti Liquid's milk production enhancement functionality.

Extracts of Piper longum (Long Pepper / Pipli) 400 mg per 100 ml: Piper longum (Long Pepper) is included in the Calshakti Liquid formula in its role as a bioavailability enhancer a function well-established in Ayurvedic pharmacology through the principle of Yogavahi (carrier enhancement) and increasingly validated in modern pharmacokinetic research. The primary active alkaloid of Piper longum, piperine, inhibits intestinal P-glycoprotein efflux transporters and cytochrome P450 3A4 (CYP3A4) enzymes in the gastrointestinal mucosa and liver molecular mechanisms that normally limit the absorption and systemic availability of many nutrients and phytochemicals. By suppressing these efflux and metabolic barriers, piperine significantly enhances the intestinal absorption and plasma bioavailability of the mineral actives (calcium, phosphorus), vitamins (D3, B12), and herbal extracts (Shatavari, Jivanti) co-administered in Calshakti Liquid. This means that more of every active ingredient delivered per dose is actually absorbed and utilised by the animal's body, amplifying the clinical return on each serving. Piper longum also exhibits mild rumenotonic and digestive stimulant properties in ruminants, supporting healthy rumen motility and appetite during the transition period.