INJECTABLE
  • Animeal

INJECTABLE

DUROMECT INJECTION (S)

DUROMECT INJECTION (S)

By ZYDUS

₹ 261.36
-10% off ₹ 261.36 M.R.P: ₹ 290.40
Unlock Unbeatable offers! WhatsApp us now
Tax included. Shipping calculated at checkout.

Out of Stock

Expires on or after: Feb, 2027

Prescription Required question

Title
Size
10mL ₹ 290.40
50mL ₹ 1,210

Check Availability

Rapid 3-4 Day Delivery,Tiny Extra Fee!

  • AnimealPet Safe
  • AnimealBest Quality
  • AnimealFast Delivery
  • AnimealSecure Payment
View full details

The Duromect Doramectin Injection by Zydus AHL is a cutting-edge, long-acting, broad-spectrum parasiticide formulated as a ready-to-use sterile oily solution containing 10 mg of Doramectin per ml. It is indicated for the treatment and control of a wide and clinically significant range of internal and external parasites in dogs, cats, cattle, sheep, goats, and swine. Parasitic infestations represent one of the most pervasive and economically consequential health challenges facing both companion animals and livestock, causing gastrointestinal damage, anemia, weight loss, dermal disorders, and in severe cases, life-threatening systemic compromise. Duromect targets this burden with a potent macrocyclic lactone formulation derived from a genetically altered strain of the soil bacterium Streptomyces avermitilis, delivering a sustained pharmacological effect that eliminates a broad spectrum of nematodes, arthropods, mites, lice, and ticks through a precise and well-understood neurological mechanism. Available in both 10 ml and 50 ml vials to serve the needs of individual pet owners under veterinary guidance as well as large-scale livestock operations, Duromect is the preferred choice of veterinarians requiring a dependable, low-volume injectable parasiticide with a proven safety profile and wide-spectrum coverage. Animeal is proud to offer Duromect Doramectin Injection as part of its veterinary pharmaceutical range for discerning pet parents and animal care professionals who trust only the best for the animals in their care.

Ingredients:

Doramectin, 10 mg per ml: Doramectin is a macrocyclic lactone belonging to the avermectin class of antiparasitic compounds. It is derived through fermentation of a genetically altered strain of the gram-positive soil actinomycete Streptomyces avermitilis, employing a modified biosynthetic pathway that produces a cyclohexyl-substituted compound with a significantly extended half-life compared to structurally related molecules such as ivermectin. At the cellular level, Doramectin exerts its parasitocidal effect by selectively binding to glutamate-gated chloride ion channels, which are found exclusively in invertebrate nerve and muscle cells and are absent in mammals. This binding potentiates chloride ion influx across the cell membrane, increasing membrane permeability and hyperpolarising the nerve or muscle cell. The resulting blockade of electrical activity in nematode nerve cells and arthropod muscle cells produces irreversible flaccid paralysis and subsequent death of the parasite. Doramectin also potentiates the activity of gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter, at presynaptic neurons of susceptible parasites, further reinforcing the neuromuscular shutdown. Because mammalian GABA-gated chloride channels are structurally distinct and because Doramectin does not readily cross the intact blood-brain barrier at therapeutic doses, the compound demonstrates a wide margin of safety in target host species when administered as directed.

Benzyl Alcohol IP, 20 mg per ml (as preservative): Benzyl Alcohol is a pharmaceutical-grade aromatic alcohol included at 20 mg/ml as an antimicrobial preservative. It maintains the sterility of the multi-use vial by inhibiting the growth of bacteria and fungi that could compromise the product between doses, thereby ensuring that each withdrawal from the vial delivers a sterile, uncontaminated injectable solution.

Oily Base, Quantity Sufficient: The oily vehicle in which Doramectin is suspended is a critical component of the product's pharmacokinetic profile. The lipophilic base ensures slow, sustained release of Doramectin from the intramuscular or subcutaneous depot following injection, contributing to the compound's long duration of action and enabling persistent plasma levels that provide extended post-treatment protection against reinfection.

Broad-Spectrum Single-Injection Parasite Control:
A single administration of Duromect targets a comprehensive range of both internal parasites (roundworms, lungworms, eyeworms) and external parasites (mites, lice, ticks, screwworms) simultaneously, eliminating the need for multiple antiparasitic agents and simplifying treatment protocols for veterinarians managing complex or mixed infestations. This dual internal and external efficacy within one injection is a defining advantage of Doramectin over narrower-spectrum antiparasitics.

Extended Duration of Action and Persistent Protection:
The lipophilic oily depot formulation ensures that Doramectin is absorbed gradually from the injection site, maintaining effective plasma concentrations for extended periods following a single dose. This persistent pharmacokinetic profile provides protection against reinfestation after treatment, with documented protective intervals of up to 35 days against Ostertagia ostertagi and Dictyocaulus viviparus in cattle, up to 28 days against Haemonchus placei and sucking lice, and up to 42 days against Psoroptes bovis mange mites, substantially reducing the frequency of retreatment required.

Safe for Use in Ivermectin-Sensitive Breeds:
One of the most clinically significant distinguishing features of Duromect is its reported safety profile in dog breeds carrying the MDR1 (ABCB1) gene mutation, such as Collies, Shetland Sheepdogs, Australian Shepherds, and related herding breeds. These breeds are known to have increased blood-brain barrier permeability to many macrocyclic lactones, particularly ivermectin. Doramectin, used at veterinarian-prescribed doses via the subcutaneous route, has been documented in literature to be tolerable in these sensitive breeds for the treatment of generalised demodicosis, making it a valuable clinical option where ivermectin may be contraindicated.

Low-Volume Injection for Minimal Animal Stress:
Duromect is a concentrated, low-volume formulation that delivers the full therapeutic dose in a small injection volume, reducing the physical burden on the animal and minimising tissue trauma at the injection site. For livestock operations requiring treatment of large numbers of animals, this translates to faster administration, reduced animal handling stress, and improved operator efficiency without compromising treatment efficacy.

Supports Herd Health, Productivity, and Weight Performance:
In livestock, parasitic burdens are a primary cause of impaired feed conversion, reduced weight gain, decreased milk production, and compromised reproductive performance. By systematically eliminating both internal and external parasites, regular strategic use of Duromect as part of a veterinarian-guided parasite management programme directly supports the productive capacity and overall health of your herd, delivering measurable economic and welfare benefits.

How to Use:

Duromect Doramectin Injection must be administered exclusively by a qualified veterinarian or veterinary professional and must not be self-administered by animal owners or farm workers without direct veterinary instruction and supervision. The product is a pale yellow, ready-to-use sterile solution supplied in 10 ml and 50 ml vials. For cattle, sheep, and goats, the injection is administered via the intramuscular or subcutaneous route at a dosage rate corresponding to body weight, with the neck region being the recommended site for cattle to comply with Beef Quality Assurance guidelines. For swine, the injection is given by the intramuscular route only. For dogs and cats in cases of generalised demodicosis, administration is by the subcutaneous route at the dosage and frequency determined by the attending veterinarian. The exact dose must always be calculated based on a current, accurate body weight; underdosing may result in treatment failure and can contribute to the development of parasite resistance. Use a clean needle for each injection and withdraw from the vial aseptically. Do not mix with other products in the same syringe. Sheep and goats should be vaccinated against enterotoxemia or pulpy kidney disease before treatment with Duromect. Vaccination against broad-spectrum Clostridium infections is strongly recommended in cattle, sheep, and goats prior to or concurrent with treatment. The number of withdrawals from a single vial must not exceed ten.

Storage Advice

Store unopened Duromect Doramectin Injection vials in a cool, dry place below 30 degrees C, away from direct sunlight and heat sources. Do not freeze. Once a vial has been broached, reseal immediately after withdrawal using a clean sterile needle to maintain aseptic conditions, and do not exceed ten withdrawals from any single vial. Store broached vials under the same temperature conditions and use within the period recommended by your veterinarian. Do not use after the best-before date printed on the vial label or outer carton. Keep out of reach of uninformed persons and children at all times.

About the Brand:

Zydus AHL (Zydus Animal Health and Investments Limited) is the animal health division of Zydus Lifesciences Limited, formerly known as Cadila Healthcare Limited, a fully integrated Indian pharmaceutical group with origins tracing back to 1952 and an operational presence in animal health spanning more than six decades. As one of India's leading animal health companies, Zydus AHL holds leadership positions across antimicrobials, vitamin injectables, corticosteroids, hormones, anti-mastitis products, and antiparasitic formulations, supported by the Zydus Group's state-of-the-art Pharmaceutical Technology Centre, which drives new product development, novel delivery research, and rigorous stability and toxicological testing. Zydus AHL operates through species-based strategic business units supported by a technically trained field force that provides round-the-clock veterinary and agricultural support across India, and has partnered globally with Phibro AHC for co-marketing of international animal health products, reflecting a product philosophy grounded in comprehensive health coverage, quality manufacturing, and cost-effective innovation that aligns with Animeal's commitment to offering only trusted, evidence-based pharmaceutical solutions for your animals. Discover Zydus AHL today.

Disclaimer:

Please note that while Duromect Doramectin Injection is formulated from pharmaceutical-grade Doramectin (10 mg/ml) with Benzyl Alcohol as preservative in an oily base, and is appropriate for use in cattle, sheep, goats, swine, dogs, and cats under veterinary supervision, it is a prescription-only injectable parasiticide and must not be purchased, stored, or administered without a valid veterinary prescription and direct veterinary oversight. This product is not a complete antiparasitic solution in isolation; it must be used as part of a veterinarian-guided, integrated parasite management programme that accounts for local parasite resistance patterns, seasonal epidemiology, and species-specific risk factors. Meat withdrawal periods apply: 28 days for meat and 7 days for milk in livestock; treated animals must not be slaughtered for human consumption before the expiry of these periods. This product must not be used in animals producing milk for human consumption. For pets and livestock with known or suspected MDR1 gene mutations, hepatic disease, or prior hypersensitivity to macrocyclic lactones, consult your veterinarian before introducing this product. Animeal supports your pet's health and happiness journey but does not replace the advice of a qualified veterinary professional.

Q: Which animals and life stages is Duromect Doramectin Injection suitable for?
Duromect is indicated for use in cattle, sheep, goats, swine, and under specific veterinary prescription, dogs and cats (primarily for the treatment of generalised demodicosis). It is used across adult animals and, where appropriate, in younger animals under direct veterinary dosing guidance. It is not recommended for use in dairy cows producing milk for human consumption, or in animals within the established withdrawal period prior to slaughter. Use in pregnant or lactating animals should be evaluated by a veterinarian on a case-by-case basis.
Q: How frequently should Duromect be administered?
The frequency of administration is entirely at the discretion of the attending veterinarian, based on the severity of parasitic infestation, the species and weight of the animal, the local epidemiology of parasitic disease, and the established persistent protection intervals of the product against specific parasites. In livestock, strategic dosing is often timed at the start and end of the grazing season. In dogs with demodicosis, the treating veterinarian will determine the interval and total course duration based on clinical response and skin scraping results.
Q: How effective is Duromect against mange mites and gastrointestinal worms in livestock and pets?
Doramectin, the active ingredient in Duromect, is widely regarded as one of the most potent and clinically validated macrocyclic lactones available for veterinary use, with documented high efficacy rates against a comprehensive range of gastrointestinal nematodes, lungworms, sucking lice, and mange mites including Sarcoptes, Psoroptes, and Chorioptes species. In dogs, doramectin-based protocols for generalised demodicosis have demonstrated clinical resolution in cases refractory to other treatments. The extended-release oily depot formulation provides persistent plasma levels that continue to act on migrating larval stages and newly acquired parasites well beyond the point of administration.
Q: Are there any safety concerns or side effects associated with Duromect?
When used at veterinarian-prescribed doses and via the correct route of administration, Duromect has a well-established wide safety margin in mammals, owing to Doramectin's inability to readily penetrate the mammalian blood-brain barrier at therapeutic concentrations. Side effects are uncommon but may include transient swelling or mild discomfort at the injection site. Overdosage, incorrect route of administration, or use in animals with compromised blood-brain barrier function may cause neurological signs including ataxia, tremors, or mydriasis. Animals known to carry the MDR1 (ABCB1) gene mutation require veterinary evaluation before use. Doramectin must not be used in animals with a known hypersensitivity to avermectins.
Q: What makes Duromect different from ivermectin-based injectable parasiticides?
While Doramectin and ivermectin share the same avermectin class and basic mechanism of action, Doramectin's unique cyclohexyl substituent group, introduced through a modified biosynthetic fermentation pathway, confers a significantly longer half-life and a more sustained duration of action compared to standard ivermectin formulations. This translates to a meaningfully extended post-treatment protection window against key parasites. Additionally, Doramectin has been documented in veterinary literature to have a more favourable tolerability profile in MDR1-mutant dog breeds such as Collies compared to ivermectin, making Duromect a clinically valuable alternative in cases where ivermectin carries a higher risk of neurotoxicity. The oily depot vehicle further differentiates Duromect by sustaining effective plasma concentrations beyond what aqueous injectable formulations of comparable compounds can achieve.
DUROMECT INJECTION (S) - Animeal
INJECTABLE
🚚 Free above ₹499 in Mumbai · ₹1499 outside
10 DaysEasy Returns
100%Authentic
SecurePayments
INJECTABLE

DUROMECT INJECTION (S)

By ZYDUS
₹ 261.36
You save ₹ 29.04 (10%)
MRP ₹ 290.40 (Incl. taxes)

Out of Stock

Expires on or after: May, 2026
Size

Prescription Required question

₹ 261.36
MRP ₹ 290.40  10% OFF
1
Check Availability

The Duromect Doramectin Injection by Zydus AHL is a cutting-edge, long-acting, broad-spectrum parasiticide formulated as a ready-to-use sterile oily solution containing 10 mg of Doramectin per ml. It is indicated for the treatment and control of a wide and clinically significant range of internal and external parasites in dogs, cats, cattle, sheep, goats, and swine. Parasitic infestations represent one of the most pervasive and economically consequential health challenges facing both companion animals and livestock, causing gastrointestinal damage, anemia, weight loss, dermal disorders, and in severe cases, life-threatening systemic compromise. Duromect targets this burden with a potent macrocyclic lactone formulation derived from a genetically altered strain of the soil bacterium Streptomyces avermitilis, delivering a sustained pharmacological effect that eliminates a broad spectrum of nematodes, arthropods, mites, lice, and ticks through a precise and well-understood neurological mechanism. Available in both 10 ml and 50 ml vials to serve the needs of individual pet owners under veterinary guidance as well as large-scale livestock operations, Duromect is the preferred choice of veterinarians requiring a dependable, low-volume injectable parasiticide with a proven safety profile and wide-spectrum coverage. Animeal is proud to offer Duromect Doramectin Injection as part of its veterinary pharmaceutical range for discerning pet parents and animal care professionals who trust only the best for the animals in their care.

Ingredients:

Doramectin, 10 mg per ml: Doramectin is a macrocyclic lactone belonging to the avermectin class of antiparasitic compounds. It is derived through fermentation of a genetically altered strain of the gram-positive soil actinomycete Streptomyces avermitilis, employing a modified biosynthetic pathway that produces a cyclohexyl-substituted compound with a significantly extended half-life compared to structurally related molecules such as ivermectin. At the cellular level, Doramectin exerts its parasitocidal effect by selectively binding to glutamate-gated chloride ion channels, which are found exclusively in invertebrate nerve and muscle cells and are absent in mammals. This binding potentiates chloride ion influx across the cell membrane, increasing membrane permeability and hyperpolarising the nerve or muscle cell. The resulting blockade of electrical activity in nematode nerve cells and arthropod muscle cells produces irreversible flaccid paralysis and subsequent death of the parasite. Doramectin also potentiates the activity of gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter, at presynaptic neurons of susceptible parasites, further reinforcing the neuromuscular shutdown. Because mammalian GABA-gated chloride channels are structurally distinct and because Doramectin does not readily cross the intact blood-brain barrier at therapeutic doses, the compound demonstrates a wide margin of safety in target host species when administered as directed.

Benzyl Alcohol IP, 20 mg per ml (as preservative): Benzyl Alcohol is a pharmaceutical-grade aromatic alcohol included at 20 mg/ml as an antimicrobial preservative. It maintains the sterility of the multi-use vial by inhibiting the growth of bacteria and fungi that could compromise the product between doses, thereby ensuring that each withdrawal from the vial delivers a sterile, uncontaminated injectable solution.

Oily Base, Quantity Sufficient: The oily vehicle in which Doramectin is suspended is a critical component of the product's pharmacokinetic profile. The lipophilic base ensures slow, sustained release of Doramectin from the intramuscular or subcutaneous depot following injection, contributing to the compound's long duration of action and enabling persistent plasma levels that provide extended post-treatment protection against reinfection.

Broad-Spectrum Single-Injection Parasite Control:
A single administration of Duromect targets a comprehensive range of both internal parasites (roundworms, lungworms, eyeworms) and external parasites (mites, lice, ticks, screwworms) simultaneously, eliminating the need for multiple antiparasitic agents and simplifying treatment protocols for veterinarians managing complex or mixed infestations. This dual internal and external efficacy within one injection is a defining advantage of Doramectin over narrower-spectrum antiparasitics.

Extended Duration of Action and Persistent Protection:
The lipophilic oily depot formulation ensures that Doramectin is absorbed gradually from the injection site, maintaining effective plasma concentrations for extended periods following a single dose. This persistent pharmacokinetic profile provides protection against reinfestation after treatment, with documented protective intervals of up to 35 days against Ostertagia ostertagi and Dictyocaulus viviparus in cattle, up to 28 days against Haemonchus placei and sucking lice, and up to 42 days against Psoroptes bovis mange mites, substantially reducing the frequency of retreatment required.

Safe for Use in Ivermectin-Sensitive Breeds:
One of the most clinically significant distinguishing features of Duromect is its reported safety profile in dog breeds carrying the MDR1 (ABCB1) gene mutation, such as Collies, Shetland Sheepdogs, Australian Shepherds, and related herding breeds. These breeds are known to have increased blood-brain barrier permeability to many macrocyclic lactones, particularly ivermectin. Doramectin, used at veterinarian-prescribed doses via the subcutaneous route, has been documented in literature to be tolerable in these sensitive breeds for the treatment of generalised demodicosis, making it a valuable clinical option where ivermectin may be contraindicated.

Low-Volume Injection for Minimal Animal Stress:
Duromect is a concentrated, low-volume formulation that delivers the full therapeutic dose in a small injection volume, reducing the physical burden on the animal and minimising tissue trauma at the injection site. For livestock operations requiring treatment of large numbers of animals, this translates to faster administration, reduced animal handling stress, and improved operator efficiency without compromising treatment efficacy.

Supports Herd Health, Productivity, and Weight Performance:
In livestock, parasitic burdens are a primary cause of impaired feed conversion, reduced weight gain, decreased milk production, and compromised reproductive performance. By systematically eliminating both internal and external parasites, regular strategic use of Duromect as part of a veterinarian-guided parasite management programme directly supports the productive capacity and overall health of your herd, delivering measurable economic and welfare benefits.

How to Use:

Duromect Doramectin Injection must be administered exclusively by a qualified veterinarian or veterinary professional and must not be self-administered by animal owners or farm workers without direct veterinary instruction and supervision. The product is a pale yellow, ready-to-use sterile solution supplied in 10 ml and 50 ml vials. For cattle, sheep, and goats, the injection is administered via the intramuscular or subcutaneous route at a dosage rate corresponding to body weight, with the neck region being the recommended site for cattle to comply with Beef Quality Assurance guidelines. For swine, the injection is given by the intramuscular route only. For dogs and cats in cases of generalised demodicosis, administration is by the subcutaneous route at the dosage and frequency determined by the attending veterinarian. The exact dose must always be calculated based on a current, accurate body weight; underdosing may result in treatment failure and can contribute to the development of parasite resistance. Use a clean needle for each injection and withdraw from the vial aseptically. Do not mix with other products in the same syringe. Sheep and goats should be vaccinated against enterotoxemia or pulpy kidney disease before treatment with Duromect. Vaccination against broad-spectrum Clostridium infections is strongly recommended in cattle, sheep, and goats prior to or concurrent with treatment. The number of withdrawals from a single vial must not exceed ten.

Storage Advice

Store unopened Duromect Doramectin Injection vials in a cool, dry place below 30 degrees C, away from direct sunlight and heat sources. Do not freeze. Once a vial has been broached, reseal immediately after withdrawal using a clean sterile needle to maintain aseptic conditions, and do not exceed ten withdrawals from any single vial. Store broached vials under the same temperature conditions and use within the period recommended by your veterinarian. Do not use after the best-before date printed on the vial label or outer carton. Keep out of reach of uninformed persons and children at all times.

About the Brand:

Zydus AHL (Zydus Animal Health and Investments Limited) is the animal health division of Zydus Lifesciences Limited, formerly known as Cadila Healthcare Limited, a fully integrated Indian pharmaceutical group with origins tracing back to 1952 and an operational presence in animal health spanning more than six decades. As one of India's leading animal health companies, Zydus AHL holds leadership positions across antimicrobials, vitamin injectables, corticosteroids, hormones, anti-mastitis products, and antiparasitic formulations, supported by the Zydus Group's state-of-the-art Pharmaceutical Technology Centre, which drives new product development, novel delivery research, and rigorous stability and toxicological testing. Zydus AHL operates through species-based strategic business units supported by a technically trained field force that provides round-the-clock veterinary and agricultural support across India, and has partnered globally with Phibro AHC for co-marketing of international animal health products, reflecting a product philosophy grounded in comprehensive health coverage, quality manufacturing, and cost-effective innovation that aligns with Animeal's commitment to offering only trusted, evidence-based pharmaceutical solutions for your animals. Discover Zydus AHL today.

Disclaimer:

Please note that while Duromect Doramectin Injection is formulated from pharmaceutical-grade Doramectin (10 mg/ml) with Benzyl Alcohol as preservative in an oily base, and is appropriate for use in cattle, sheep, goats, swine, dogs, and cats under veterinary supervision, it is a prescription-only injectable parasiticide and must not be purchased, stored, or administered without a valid veterinary prescription and direct veterinary oversight. This product is not a complete antiparasitic solution in isolation; it must be used as part of a veterinarian-guided, integrated parasite management programme that accounts for local parasite resistance patterns, seasonal epidemiology, and species-specific risk factors. Meat withdrawal periods apply: 28 days for meat and 7 days for milk in livestock; treated animals must not be slaughtered for human consumption before the expiry of these periods. This product must not be used in animals producing milk for human consumption. For pets and livestock with known or suspected MDR1 gene mutations, hepatic disease, or prior hypersensitivity to macrocyclic lactones, consult your veterinarian before introducing this product. Animeal supports your pet's health and happiness journey but does not replace the advice of a qualified veterinary professional.

Q: Which animals and life stages is Duromect Doramectin Injection suitable for?
Duromect is indicated for use in cattle, sheep, goats, swine, and under specific veterinary prescription, dogs and cats (primarily for the treatment of generalised demodicosis). It is used across adult animals and, where appropriate, in younger animals under direct veterinary dosing guidance. It is not recommended for use in dairy cows producing milk for human consumption, or in animals within the established withdrawal period prior to slaughter. Use in pregnant or lactating animals should be evaluated by a veterinarian on a case-by-case basis.
Q: How frequently should Duromect be administered?
The frequency of administration is entirely at the discretion of the attending veterinarian, based on the severity of parasitic infestation, the species and weight of the animal, the local epidemiology of parasitic disease, and the established persistent protection intervals of the product against specific parasites. In livestock, strategic dosing is often timed at the start and end of the grazing season. In dogs with demodicosis, the treating veterinarian will determine the interval and total course duration based on clinical response and skin scraping results.
Q: How effective is Duromect against mange mites and gastrointestinal worms in livestock and pets?
Doramectin, the active ingredient in Duromect, is widely regarded as one of the most potent and clinically validated macrocyclic lactones available for veterinary use, with documented high efficacy rates against a comprehensive range of gastrointestinal nematodes, lungworms, sucking lice, and mange mites including Sarcoptes, Psoroptes, and Chorioptes species. In dogs, doramectin-based protocols for generalised demodicosis have demonstrated clinical resolution in cases refractory to other treatments. The extended-release oily depot formulation provides persistent plasma levels that continue to act on migrating larval stages and newly acquired parasites well beyond the point of administration.
Q: Are there any safety concerns or side effects associated with Duromect?
When used at veterinarian-prescribed doses and via the correct route of administration, Duromect has a well-established wide safety margin in mammals, owing to Doramectin's inability to readily penetrate the mammalian blood-brain barrier at therapeutic concentrations. Side effects are uncommon but may include transient swelling or mild discomfort at the injection site. Overdosage, incorrect route of administration, or use in animals with compromised blood-brain barrier function may cause neurological signs including ataxia, tremors, or mydriasis. Animals known to carry the MDR1 (ABCB1) gene mutation require veterinary evaluation before use. Doramectin must not be used in animals with a known hypersensitivity to avermectins.
Q: What makes Duromect different from ivermectin-based injectable parasiticides?
While Doramectin and ivermectin share the same avermectin class and basic mechanism of action, Doramectin's unique cyclohexyl substituent group, introduced through a modified biosynthetic fermentation pathway, confers a significantly longer half-life and a more sustained duration of action compared to standard ivermectin formulations. This translates to a meaningfully extended post-treatment protection window against key parasites. Additionally, Doramectin has been documented in veterinary literature to have a more favourable tolerability profile in MDR1-mutant dog breeds such as Collies compared to ivermectin, making Duromect a clinically valuable alternative in cases where ivermectin carries a higher risk of neurotoxicity. The oily depot vehicle further differentiates Duromect by sustaining effective plasma concentrations beyond what aqueous injectable formulations of comparable compounds can achieve.
DUROMECT INJECTION (S)
₹ 261.36
₹ 290.40  10% OFF

Frequently Asked Questions

Which animals and life stages is Duromect Doramectin Injection suitable for?

Duromect is indicated for use in cattle, sheep, goats, swine, and under specific veterinary prescription, dogs and cats (primarily for the treatment of generalised demodicosis). It is used across adult animals and, where appropriate, in younger animals under direct veterinary dosing guidance. It is not recommended for use in dairy cows producing milk for human consumption, or in animals within the established withdrawal period prior to slaughter. Use in pregnant or lactating animals should be evaluated by a veterinarian on a case-by-case basis.

How frequently should Duromect be administered?

The frequency of administration is entirely at the discretion of the attending veterinarian, based on the severity of parasitic infestation, the species and weight of the animal, the local epidemiology of parasitic disease, and the established persistent protection intervals of the product against specific parasites. In livestock, strategic dosing is often timed at the start and end of the grazing season. In dogs with demodicosis, the treating veterinarian will determine the interval and total course duration based on clinical response and skin scraping results.

How effective is Duromect against mange mites and gastrointestinal worms in livestock and pets?

Doramectin, the active ingredient in Duromect, is widely regarded as one of the most potent and clinically validated macrocyclic lactones available for veterinary use, with documented high efficacy rates against a comprehensive range of gastrointestinal nematodes, lungworms, sucking lice, and mange mites including Sarcoptes, Psoroptes, and Chorioptes species. In dogs, doramectin-based protocols for generalised demodicosis have demonstrated clinical resolution in cases refractory to other treatments. The extended-release oily depot formulation provides persistent plasma levels that continue to act on migrating larval stages and newly acquired parasites well beyond the point of administration.

Are there any safety concerns or side effects associated with Duromect?

When used at veterinarian-prescribed doses and via the correct route of administration, Duromect has a well-established wide safety margin in mammals, owing to Doramectin's inability to readily penetrate the mammalian blood-brain barrier at therapeutic concentrations. Side effects are uncommon but may include transient swelling or mild discomfort at the injection site. Overdosage, incorrect route of administration, or use in animals with compromised blood-brain barrier function may cause neurological signs including ataxia, tremors, or mydriasis. Animals known to carry the MDR1 (ABCB1) gene mutation require veterinary evaluation before use. Doramectin must not be used in animals with a known hypersensitivity to avermectins.

What makes Duromect different from ivermectin-based injectable parasiticides?

While Doramectin and ivermectin share the same avermectin class and basic mechanism of action, Doramectin's unique cyclohexyl substituent group, introduced through a modified biosynthetic fermentation pathway, confers a significantly longer half-life and a more sustained duration of action compared to standard ivermectin formulations. This translates to a meaningfully extended post-treatment protection window against key parasites. Additionally, Doramectin has been documented in veterinary literature to have a more favourable tolerability profile in MDR1-mutant dog breeds such as Collies compared to ivermectin, making Duromect a clinically valuable alternative in cases where ivermectin carries a higher risk of neurotoxicity. The oily depot vehicle further differentiates Duromect by sustaining effective plasma concentrations beyond what aqueous injectable formulations of comparable compounds can achieve.
View All Questions