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INJECTABLE
EPIDOSIN INJ
EPIDOSIN INJ
By TTK
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About Product
Epidosin Injection is a standout product in our VETERINARY OBSTETRIC & ANTISPASMODIC MEDICINE category. Manufactured by TTK Healthcare Ltd. one of India's most established and respected pharmaceutical manufacturers, headquartered in Chennai, Tamil Nadu Epidosin delivers Valethamate Bromide 10mg per ml in a convenient, ready-to-use 30ml multi-dose vial format ideally suited for large animal veterinary field practice. Valethamate Bromide is a potent, rapidly acting parasympatholytic agent that exerts simultaneous cholinolytic, spasmolytic, and musculotropic actions on the smooth muscles of the gastrointestinal, genitourinary, and reproductive tracts making it an indispensable clinical tool for managing the full spectrum of veterinary obstetric emergencies and abdominal colic presentations encountered in large and small animal practice across India. With its well-established clinical efficacy, reliable rapid onset of action, and the trusted quality assurance of TTK Healthcare manufacturing, Epidosin has earned the confidence of veterinarians, dairy practitioners, and animal husbandry professionals across India as their first-line choice for smooth muscle spasm relief and parturition facilitation. With Epidosin, you can trust that you are offering every animal patient the very best in clinically proven, pharmaceutical-grade antispasmodic care.
Composition:
Each ml of Epidosin Injection contains a precisely formulated, pharmaceutical-grade composition for reliable intramuscular or intravenous delivery:
- Valethamate Bromide 10mg/ml (Active Ingredient): a quaternary ammonium anticholinergic compound classified as a potent parasympatholytic, musculotropic spasmolytic, and cholinolytic agent. Valethamate Bromide exerts its therapeutic action through a dual mechanism a peripheral anticholinergic action that competitively blocks muscarinic acetylcholine receptors on smooth muscle cells of the gastrointestinal, genitourinary, and reproductive tracts, and a direct musculotropic action that relaxes smooth muscle independently of its anticholinergic activity. This dual mechanism provides broader, more complete smooth muscle relaxation than single-mechanism antispasmodics, and explains its particular clinical utility in obstetric applications where both receptor-mediated and direct smooth muscle relaxation are required for effective cervical dilation and relief of uterine smooth muscle spasm during dystocia and kinked cervix presentations. The onset of action following intramuscular administration is rapid with clinically meaningful smooth muscle relaxation typically observed within 15 to 30 minutes of injection
- Chlorbutol IP 0.5% w/v (Preservative): a pharmaceutical-grade antimicrobial preservative that maintains the complete sterility and microbiological integrity of the multi-dose 30ml vial throughout its entire in-use period, ensuring every dose drawn from the vial is free from bacterial contamination a critical safety feature for multi-dose vials used in field veterinary practice
- Water for Injection IP (Vehicle): sterile, pyrogen-free water meeting Indian Pharmacopoeia standards for parenteral preparations, serving as the aqueous vehicle that delivers the active ingredient in a completely miscible, injectable solution form
Features and Benefits
Facilitation of Normal Parturition: the single ...
Facilitation of Normal Parturition: the single most important and widely used clinical application of Epidosin in Indian veterinary practice Valethamate Bromide's powerful spasmolytic action on uterine cervical smooth muscle actively promotes cervical softening, effacement, and dilation during the first stage of labour, significantly reducing the duration of cervical phase labour in cattle, buffaloes, and other large animals improving both dam welfare and obstetric outcomes in farm and field settings
Management of Dystocia: effectively used in cases of dystocia where delayed or incomplete cervical dilation is contributing to obstructed labour Epidosin promotes cervical relaxation and dilation that may allow vaginal delivery to proceed without the need for immediate surgical intervention, reducing the incidence of emergency caesarean section in field conditions where surgical facilities may not be immediately available
Kinked Cervix Correction: a specific and clinically validated indication that distinguishes Epidosin from many other antispasmodics the musculotropic spasmolytic action on uterine and cervical smooth muscle effectively relaxes the abnormal smooth muscle contracture responsible for cervical kinking, facilitating correction of the anatomical obstruction and enabling normal parturition progression
Abdominal & Urogenital Colic Relief: the broad smooth muscle spasmolytic activity of Valethamate Bromide provides rapid and effective relief from the pain and discomfort of gastrointestinal colic, ureteric colic, and biliary colic in both large and small animals addressing the smooth muscle spasm component of colic presentations that contributes significantly to patient distress and clinical deterioration
Support for Artificial Insemination (AI) Procedures: used routinely by dairy veterinarians and AI technicians to reduce uterine and cervical smooth muscle tone prior to and during artificial insemination procedures facilitating easier cervical passage, reducing animal discomfort during AI, and improving conception rates by eliminating the cervical spasm that can impede semen deposition at the optimal intrauterine site
Uterine Prolapse Management (Adjunct): used as part of the clinical management protocol for uterine prolapse cases to reduce smooth muscle spasm and facilitate manual replacement of the prolapsed uterine tissue reducing the force required for replacement and minimising the risk of further trauma to the prolapsed tissue during the replacement procedure
Rapid Onset for Clinical Emergencies: the rapid onset of meaningful smooth muscle relaxation within 15 to 30 minutes of intramuscular injection makes Epidosin particularly valuable in time-sensitive obstetric emergencies where prompt clinical intervention is essential for optimal foetal and maternal outcomes
Convenient 30ml Multi-Dose Vial for Field Practice: the 30ml vial format provides sufficient volume for multiple large animal treatment doses in a single vial ideal for field veterinary practice, mobile dairy practice, and farm-level veterinary service delivery where carrying multiple small vials is impractical
Usage and Applications
How to Use:For intramuscular (IM) administratio...
How to Use:
For intramuscular (IM) administration by or under the direct supervision of a licensed veterinarian only. Draw the required dose into a sterile syringe using aseptic technique. Administer by deep intramuscular injection into an appropriate injection site the neck muscles or hindquarters are the most commonly used IM injection sites in large animals. In dogs and cats, administer into the epaxial muscles or hindlimb muscle mass as appropriate. Always use a fresh, sterile needle for each injection. Observe the patient for 20 to 30 minutes post-injection for clinical response and any adverse reactions.
Storage Advice:
Store Epidosin Injection 30ml below 25°C in a cool, dry place away from direct sunlight and heat. Do not freeze. Keep in original packaging until use. Once opened, use within the period specified on the label do not use beyond the in-use stability period. Discard any unused vial contents that show signs of particulate matter, discolouration, or compromise of vial sterility. Keep out of reach of children. Do not use after the expiry date printed on the vial label and outer carton.
About the Brand:
TTK Healthcare Ltd. is one of India's most established, respected, and trusted pharmaceutical manufacturers founded as part of the TTK Group and headquartered in Chennai, Tamil Nadu. With decades of pharmaceutical manufacturing experience across human and veterinary medicine, TTK Healthcare has built an unwavering reputation for consistent product quality, reliable active ingredient potency, and strict GMP manufacturing compliance that veterinarians and healthcare professionals across India have depended upon for generations. Their Epidosin brand has become so well-established in Indian veterinary obstetric practice that it is virtually synonymous with Valethamate Bromide itself a testament to TTK Healthcare's consistent delivery of a product that simply works, reliably and repeatedly, in the most demanding field conditions of Indian veterinary practice. TTK Healthcare's commitment to pharmaceutical excellence and accessible veterinary medicine aligns perfectly with Animeal's mission to provide registered veterinary professionals across India with reliable, quality-assured access to the best in veterinary pharmaceuticals.
Disclaimer:
Epidosin Injection is a prescription-only veterinary injectable medicine that must be prescribed, dispensed, and administered exclusively by or under the direct supervision of a licensed veterinarian. It is not available for general retail sale, over-the-counter dispensing, or self-administration under any circumstance. Use in dogs and cats requires careful dose calculation and veterinary supervision due to the species-specific sensitivity differences in anticholinergic drug response. Avoid use in animals with known tachyarrhythmia, glaucoma, prostatic hypertrophy, paralytic ileus, or severe hepatic and renal impairment. Monitor heart rate and overall patient status closely during and following administration. Animeal facilitates enquiry and procurement for registered veterinary professionals this product is available for veterinary clinic and hospital procurement only. Always refer to the current product prescribing information and consult your clinical judgement for complete prescribing and administration guidance.
