FREPRIMECAL SYRUP

Freossi Freprimecal Suspension by Fredun Pharmaceuticals Ltd is a revolutionary MCHC-based oral calcium suspension formulated to address calcium and phosphorus deficiency in dogs, cats, puppies, and kittens across all life stages. Unlike conventional inorganic calcium salts that offer poor bioavailability and cause constipation or appetite loss, Freprimecal Suspension delivers Calcium in the form of Microcrystalline Hydroxyapatite Complex (MCHC), which mirrors the natural crystalline structure of living bone and is recognised by the body as a biological calcium source rather than a foreign mineral supplement. Fortified with Vitamin D3 (Cholecalciferol) and Vitamin B12 (Cyanocobalamin), this suspension supports robust skeletal development, accelerated fracture healing, strong dental formation, and optimal calcium metabolism during growth, pregnancy, lactation, and ageing. Available in a convenient 200ml bottle, Freprimecal Suspension is suitable for dogs and cats of all breeds and ages, making calcium supplementation precise, palatable, and clinically effective. Animeal is proud to offer Freossi Freprimecal Suspension as part of our trusted range of scientifically advanced nutritional supplements for your canine and feline companions.

Ingredients:

Microcrystalline Hydroxyapatite Complex (MCHC) providing: Calcium MCHC is a biologically derived complex calcium salt manufactured from whole bone, preserving the natural crystalline matrix of living bone tissue. Unlike inorganic calcium salts such as calcium carbonate or calcium phosphate, which are dissolved and ionised before absorption, MCHC presents calcium in the microcrystalline hydroxyapatite mineral phase [Ca10(PO4)6(OH)2], the same mineral structure that forms the inorganic framework of mammalian bone. This crystalline structure provides a vastly increased surface area within the intestinal lumen, enabling calcium ions to be released progressively and absorbed directly into enterocytes via both active vitamin-D-dependent transport and passive diffusion pathways. Clinical evidence confirms that MCHC achieves significantly higher calcium bioavailability and absorption rates compared to conventional calcium supplements, without the side effects of constipation, loss of appetite, or gut toxicity that frequently accompany inorganic calcium salts. Calcium is indispensable for bone mineralisation, muscular contraction, cardiac rhythm regulation, neuromuscular signal transmission, blood coagulation, and hormone secretion in dogs and cats.

Phosphorus: Phosphorus is delivered through MCHC in the physiologically ideal 2:1 calcium-to-phosphorus ratio that mirrors the mineral composition of healthy mammalian bone. Phosphorus is the second most abundant mineral in the body and functions as a structural component of the hydroxyapatite mineral phase of bone. Beyond skeletal health, phosphorus is an essential constituent of adenosine triphosphate (ATP), the primary energy currency of all cellular metabolism, and plays a critical role in phospholipid bilayer integrity, nucleic acid synthesis, and enzyme phosphorylation. The physiological ratio of calcium and phosphorus within MCHC ensures that supplementation does not create competitive absorption interference between the two minerals, a common problem when they are supplemented separately or in incorrect ratios.

Type I Collagen and Ossein Matrix Proteins: MCHC naturally contains Type I collagen, the most abundant structural protein in the body and the dominant protein in adult bone, comprising approximately 90 to 95% of the organic bone matrix. Type I collagen provides the flexible scaffolding upon which mineral hydroxyapatite crystals are deposited, giving bone its tensile strength, fracture resistance, and capacity for elastic deformation without brittleness. Additionally, MCHC contains ossein, a complex of non-collagenous bone matrix proteins including bone morphogenetic proteins (BMPs) and growth factors that are biologically active in stimulating osteoblast activity and bone remodelling. These bone-stimulating proteins are absent in all conventional inorganic calcium supplements, making MCHC uniquely capable of not just supplying calcium substrate but actively promoting new bone formation.

Glycosaminoglycans (GAGs): Glycosaminoglycans, including chondroitin sulphate, heparan sulphate, and dermatan sulphate, are present within the MCHC matrix as natural bone ground substance components. In joint cartilage, GAGs maintain hydration and elasticity of the extracellular matrix, contributing to the shock-absorbing properties of articular cartilage. By supplying these compounds as part of the MCHC complex, Freprimecal Suspension provides incidental joint-supportive benefits alongside its primary skeletal mineralisation function, making it particularly valuable for dogs and cats with age-related joint degeneration or those recovering from orthopaedic injuries.

Trace Minerals (naturally occurring within MCHC): The MCHC matrix naturally contains a spectrum of trace minerals including zinc, copper, manganese, magnesium, iron, and boron in the proportions found in healthy whole bone. Zinc is essential for bone matrix protein synthesis and immune cell function. Copper supports collagen cross-linking, which is critical for bone tensile strength. Manganese is a cofactor for glycosyltransferase enzymes involved in GAG synthesis. These trace minerals are delivered in naturally chelated, bioavailable forms embedded within the protein matrix of MCHC, rather than as isolated inorganic salts.

Vitamin D3 (Cholecalciferol): Vitamin D3 is the physiologically active form of vitamin D in mammals, and its inclusion in Freprimecal Suspension is clinically essential because calcium absorption from the gastrointestinal tract is fundamentally dependent on the action of 1,25-dihydroxycholecalciferol (calcitriol), the hormonal form of Vitamin D3 produced in the kidneys. At the molecular level, calcitriol binds to nuclear Vitamin D receptors (VDR) in intestinal epithelial cells, upregulating the synthesis of calbindin-D9k and other calcium transport proteins that actively transfer calcium ions across the intestinal mucosa into the bloodstream. In the absence of adequate Vitamin D3, even the most bioavailable calcium source such as MCHC cannot achieve optimal absorption. Vitamin D3 additionally regulates renal calcium reabsorption, stimulates osteoblast differentiation, and modulates parathyroid hormone (PTH) secretion, maintaining tight control over blood calcium homeostasis. Dogs and cats have limited capacity for cutaneous Vitamin D3 synthesis from sunlight and therefore depend on dietary sources, making supplementation in indoor and companion animals critically important.

Vitamin B12 (Cyanocobalamin): Vitamin B12 is a water-soluble, cobalt-containing vitamin that plays an indispensable role in DNA synthesis, red blood cell maturation, myelin sheath formation in peripheral and central nervous system neurons, and methylation reactions central to amino acid and fatty acid metabolism. In the context of skeletal health, Vitamin B12 is involved in the regulation of homocysteine metabolism; elevated homocysteine has been linked in veterinary medicine to impaired collagen cross-linking and reduced bone matrix quality. Vitamin B12 also supports the energy metabolism of osteoblasts, the bone-forming cells responsible for laying down new bone matrix, ensuring that the bone remodelling process proceeds efficiently. Deficiency of Vitamin B12 in growing puppies and kittens can manifest as anaemia, neurological deficits, and growth retardation, all of which are prevented by consistent supplementation through a product like Freprimecal Suspension.