LARIAGO INJ
Out of Stock
Prescription Required
Lariago Injection 30ml, manufactured by Ipca Laboratories Ltd., is a prescription-only, parenteral anti-malarial and anti-amoebic medication formulated to address two critical parasitic health threats: malaria caused by Plasmodium species and extraintestinal amebiasis caused by Entamoeba histolytica. Malaria, transmitted through the bite of infected Anopheles mosquitoes, invades and destroys red blood cells and liver cells, producing potentially life-threatening cycles of fever, organ stress, and systemic collapse. Extraintestinal amebiasis, most commonly presenting as hepatic amoebic abscess, occurs when intestinal parasites breach the gut wall and colonise vital organs. These are serious, rapidly progressing conditions that demand fast-acting, clinically validated pharmacological intervention. Lariago Injection delivers Chloroquine at 40mg/ml in a precise parenteral formulation, allowing rapid systemic absorption and parasiticidal action that oral routes may not reliably provide in critically ill patients. Animeal is proud to offer Lariago Injection 30ml as part of our curated range of prescription veterinary and clinical-grade pharmaceuticals, supporting the welfare of animals and the medical professionals who care for them.
Ingredients:
Chloroquine Phosphate (equivalent to Chloroquine base 40mg per ml): Chloroquine (C18H26ClN3) is a 4-aminoquinoline compound with well-established anti-plasmodial and anti-amoebic pharmacological activity. At the cellular level, Chloroquine accumulates selectively within the acidic food vacuoles of intraerythrocytic Plasmodium parasites. Inside this organelle, the parasite digests haemoglobin as its primary nutrient source, a process that generates toxic ferriprotoporphyrin IX (haem) as a by-product. Under normal parasite physiology, this haem is detoxified by biocrystallisation into inert haemozoin (malaria pigment). Chloroquine intercalates with haem and blocks this biocrystallisation process, causing a rapid and lethal accumulation of free toxic haem within the parasite's vacuole. This triggers oxidative membrane disruption and parasite death. Additionally, Chloroquine raises the intralysosomal pH of parasitised cells, further impairing the proteolytic enzyme activity the parasite depends upon for survival. Its amoebicidal action operates through a similar lysosomal alkalinisation mechanism, disrupting the intracellular environment of Entamoeba histolytica trophozoites, particularly within hepatic tissue where drug concentrations are naturally high after systemic administration. The injectable formulation at 40mg/ml ensures rapid, precise bioavailability, bypassing first-pass hepatic metabolism and guaranteeing therapeutic plasma concentrations within minutes of administration.
