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METROPLOPE BOLUS

METROPLOPE BOLUS

By UNIM

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Unim Metrolope Bolus, manufactured by Unim Pharma Lab Pvt. Ltd., is a veterinary prescription-grade oral bolus formulation containing Metronidazole BP as its active pharmaceutical ingredient, indicated for the treatment and management of anaerobic bacterial infections, protozoal infestations, and associated reproductive tract disorders in large livestock animals including cattle, buffalo, sheep, and goats. Metronidazole, a second-generation nitroimidazole antibacterial and antiprotozoal compound, is one of the most clinically respected drugs in veterinary medicine for its targeted, selective action against obligate anaerobes and susceptible protozoal organisms, making it a cornerstone therapeutic option for conditions ranging from intrauterine infections and metritis to gastrointestinal anaerobic disease and trichomoniasis in farm animals. The bolus format ensures precise, convenient oral delivery with high gastrointestinal absorption, eliminating the compliance challenges associated with powdered or liquid formulations in large animal practice. Animeal is proud to offer Unim Metrolope Bolus as part of its curated veterinary prescription livestock catalogue, supporting veterinary professionals and livestock owners in accessing cutting-edge, evidence-based antimicrobial therapy for their animals.

Ingredients:

Metronidazole BP: Metronidazole is a synthetic nitroimidazole compound that exerts its bactericidal and antiprotozoal activity through a well-characterized reductive mechanism that is selectively operative in anaerobic and microaerophilic organisms. Upon oral ingestion and gastrointestinal absorption, Metronidazole is taken up by susceptible anaerobic bacteria and protozoa, where the nitro group of the molecule undergoes enzymatic reduction by intracellular electron transport proteins, particularly ferredoxin and flavodoxin, which are exclusively present in anaerobic metabolic pathways. This reduction generates short-lived, highly cytotoxic nitro radical anion intermediates. These reactive species directly attack and bind to the helical structure of microbial DNA, inducing strand breaks, loss of double-helix integrity, and impairment of DNA replication and transcription functions. The result is rapid cell death of the target organism with a bactericidal rather than bacteriostatic outcome.

Targeted Bactericidal Activity Against Anaerobic Pathogens at the DNA Level:
Unim Metrolope Bolus reinforces your livestock animal's recovery from anaerobic infection by delivering Metronidazole directly to systemic circulation via rapid oral absorption, where it targets and destroys anaerobic bacteria and protozoa through irreversible DNA damage. Because the cytotoxic mechanism is selectively operative only in organisms with anaerobic metabolic pathways, the surrounding healthy aerobic tissues and commensal flora of your animal remain largely unaffected, supporting recovery without widespread disruption of the gut ecosystem.

Broad-Spectrum Antiprotozoal and Antibacterial Coverage in a Single Bolus:
Unlike narrow-spectrum antibiotics that target only bacterial pathogens, Unim Metrolope Bolus simultaneously addresses both anaerobic bacterial infections and protozoal infestations including Trichomonas, Giardia, and Histomonas species, making it a versatile and highly efficient therapeutic choice across a range of mixed-pathogen conditions commonly encountered in livestock. This dual spectrum reduces the need for multiple concurrent antimicrobial interventions and streamlines the treatment regimen for your herd.

Excellent Tissue Penetration Including Reproductive Tract and Peritoneal Cavity:
Metronidazole's high bioavailability and lipophilic character after oral absorption allow it to achieve therapeutic concentrations across a wide range of target tissues, including the uterine wall, peritoneal lining, and soft tissue sites of infection. This makes Unim Metrolope Bolus particularly effective in the management of post-partum metritis, retained placenta complications, and reproductive tract anaerobic infections, which are among the most economically impactful health challenges in dairy and breeding livestock herds.

Convenient Bolus Format for Precise, Stress-Reduced Administration:
The solid bolus format of Unim Metrolope eliminates the dose measurement variability and spill risk inherent in liquid or powder preparations, ensuring that your livestock animal receives the full prescribed dose with each administration. The compact bolus can be delivered rapidly using a standard balling gun, minimizing animal restraint time and handler stress while supporting compliance with multi-day treatment protocols on working farms.

Rapid Absorption and Onset of Therapeutic Action:
Following oral administration, Metronidazole is absorbed efficiently from the ruminant gastrointestinal tract, achieving plasma concentrations sufficient for antimicrobial activity within a clinically meaningful timeframe. Consistent daily administration as prescribed by your veterinarian ensures that plasma levels are maintained at or above minimum inhibitory concentrations for susceptible organisms throughout the treatment course, supporting thorough bacterial and protozoal clearance and reducing the risk of incomplete eradication.

Compatible with Multi-Drug Protocols for Mixed Infections:
Metronidazole's exclusive activity against obligate anaerobes means it is pharmacologically compatible with and clinically complementary to aerobic-spectrum antibiotics such as penicillins, aminoglycosides, and cephalosporins in the management of mixed aerobic-anaerobic infections. Under veterinary guidance, Unim Metrolope Bolus can be incorporated into combination treatment protocols targeting complex infections involving both aerobic and anaerobic pathogen components, reinforcing overall therapeutic efficacy.

How to Use:

Unim Metrolope Bolus must be administered exclusively under the direction and supervision of a registered veterinary physician. The dose, treatment duration, and route of administration will be individually determined by your veterinarian based on the livestock animal's species, body weight, nature of infection, and clinical assessment.

Storage Advice:

Store unopened Unim Metrolope Bolus in a cool, dry place below 25 degrees Celsius, away from direct sunlight, moisture, and heat sources. Do not freeze. Once the strip or container has been opened, reseal securely and use remaining boluses within the period specified on the packaging. Keep out of reach of children and non-target animals at all times. Do not use after the best-before date printed on the strip or outer carton.

About the Brand:

Unim Pharma Lab Pvt. Ltd. was established in 1999 in Himatnagar, Gujarat, India, with a founding commitment to developing trustworthy, high-quality veterinary medicines and feed supplements that address the real-world health challenges of livestock, poultry, aquaculture, equine, and companion animals across domestic and international markets. The company holds ISO 9001:2008, WHO-GMP, and GLP certifications, and manufactures more than 150 veterinary formulations across diverse dosage forms including oral liquids, powders, tablets, boluses, sprays, and herbal products from WHO-GMP-compliant manufacturing facilities, with a distribution presence spanning South America, Asia, Africa, and Europe. Unim Pharma's R&D philosophy centers on developing cost-effective, clinically validated formulations that guarantee quality, safety, and efficacy for practitioners and livestock owners operating at every level of scale, guided by an unwavering commitment to animal ethics and the highest standards of pharmaceutical manufacturing integrity. This dedication to accessible, quality-first animal healthcare aligns with Animeal's commitment to bringing veterinary-grade, evidence-based products to the animals and animal owners who depend on them most. Discover Unim Pharma today.

Disclaimer:

Please note that while Unim Metrolope Bolus is formulated from Metronidazole BP, a clinically validated nitroimidazole antibacterial and antiprotozoal agent, and is appropriate for use in large livestock animals including cattle, buffalo, sheep, and goats under veterinary supervision, it is a prescription-only veterinary pharmaceutical and is not suitable for unsupervised farm use or administration without a valid veterinary prescription. The use of metronidazole in food-producing animals is subject to regulatory restrictions that vary by country and jurisdiction; in certain markets including the United States, extra-label use of nitroimidazoles in food-producing species is prohibited under federal regulations, and livestock owners must confirm compliance with applicable local regulatory requirements with their veterinarian before use. Mandatory meat and milk withdrawal periods must be strictly observed following treatment to prevent residue entry into the food chain. For livestock animals with a history of hepatic or renal impairment, seizure disorders, or known hypersensitivity to nitroimidazoles, consult your veterinarian before introducing this product. Animeal supports your pet's health and happiness journey but does not replace the advice of a qualified veterinary professional.

Q: Which animal species and conditions is Unim Metrolope Bolus suitable for?
Unim Metrolope Bolus is formulated for use in large livestock species including cattle, buffalo, sheep, and goats, and is indicated for a range of anaerobic bacterial and protozoal conditions including metritis, endometritis, post-partum uterine infections, gastrointestinal anaerobic infections, clostridiosis, bovine trichomoniasis, foot rot with anaerobic involvement, and other tissue infections involving obligate anaerobes. It is not recommended for use in pregnant animals, particularly in the first trimester, nor in very young neonatal animals without explicit veterinary direction. Any use must be preceded by veterinary examination and formal prescription.
Q: How often and for how long should Unim Metrolope Bolus be administered?
The frequency and duration of treatment with Unim Metrolope Bolus are determined entirely by the attending veterinarian based on the individual animal's body weight, species, severity of infection, and clinical response. In general veterinary practice, oral metronidazole bolus therapy in large animals is typically administered once daily for five to seven days as a treatment course. For intrauterine applications, the number of boluses and administration frequency will be specifically directed by your veterinarian. Under no circumstances should dosing schedules be self-adjusted without veterinary guidance.
Q: How effective is Unim Metrolope Bolus against anaerobic infections and protozoal disease in livestock?
Metronidazole is recognized by veterinary pharmacologists as one of the most effective agents available against obligate anaerobic bacterial pathogens and susceptible protozoal organisms, with decades of clinical use in both small and large animal medicine confirming its bactericidal potency and broad antiprotozoal spectrum. For uterine infections caused by anaerobic bacteria, intrauterine and systemic metronidazole therapy has been consistently associated with clearance of pathogens including Bacteroides and Fusobacterium species. For protozoal conditions such as trichomoniasis, peer-reviewed research has documented efficacy in reducing organism burden and supporting reproductive recovery. The full therapeutic benefit is contingent on completing the prescribed treatment course and accurate dosing by body weight.
Q: Are there any side effects or safety concerns associated with Unim Metrolope Bolus?
When administered at prescribed doses under veterinary supervision, Metronidazole bolus therapy is generally well tolerated in large livestock animals. Potential adverse effects at standard therapeutic doses are uncommon but may include transient gastrointestinal disturbance. At high doses, neurological signs including ataxia, muscle tremors, and disorientation have been reported in susceptible animals, particularly those with pre-existing hepatic compromise; these resolve upon dose adjustment or discontinuation. Metronidazole should not be used in pregnant animals in the first trimester, in lactating animals where withdrawal requirements cannot be observed, or in animals with known hypersensitivity to nitroimidazoles. Any unexpected adverse signs following administration should be reported to your veterinarian immediately.
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GASTRO INTESTINAL AND DIGESTIVE CARE

METROPLOPE BOLUS

By UNIM
₹ 50.49
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MRP ₹ 56.10 (Incl. taxes)

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Unim Metrolope Bolus, manufactured by Unim Pharma Lab Pvt. Ltd., is a veterinary prescription-grade oral bolus formulation containing Metronidazole BP as its active pharmaceutical ingredient, indicated for the treatment and management of anaerobic bacterial infections, protozoal infestations, and associated reproductive tract disorders in large livestock animals including cattle, buffalo, sheep, and goats. Metronidazole, a second-generation nitroimidazole antibacterial and antiprotozoal compound, is one of the most clinically respected drugs in veterinary medicine for its targeted, selective action against obligate anaerobes and susceptible protozoal organisms, making it a cornerstone therapeutic option for conditions ranging from intrauterine infections and metritis to gastrointestinal anaerobic disease and trichomoniasis in farm animals. The bolus format ensures precise, convenient oral delivery with high gastrointestinal absorption, eliminating the compliance challenges associated with powdered or liquid formulations in large animal practice. Animeal is proud to offer Unim Metrolope Bolus as part of its curated veterinary prescription livestock catalogue, supporting veterinary professionals and livestock owners in accessing cutting-edge, evidence-based antimicrobial therapy for their animals.

Ingredients:

Metronidazole BP: Metronidazole is a synthetic nitroimidazole compound that exerts its bactericidal and antiprotozoal activity through a well-characterized reductive mechanism that is selectively operative in anaerobic and microaerophilic organisms. Upon oral ingestion and gastrointestinal absorption, Metronidazole is taken up by susceptible anaerobic bacteria and protozoa, where the nitro group of the molecule undergoes enzymatic reduction by intracellular electron transport proteins, particularly ferredoxin and flavodoxin, which are exclusively present in anaerobic metabolic pathways. This reduction generates short-lived, highly cytotoxic nitro radical anion intermediates. These reactive species directly attack and bind to the helical structure of microbial DNA, inducing strand breaks, loss of double-helix integrity, and impairment of DNA replication and transcription functions. The result is rapid cell death of the target organism with a bactericidal rather than bacteriostatic outcome.

Targeted Bactericidal Activity Against Anaerobic Pathogens at the DNA Level:
Unim Metrolope Bolus reinforces your livestock animal's recovery from anaerobic infection by delivering Metronidazole directly to systemic circulation via rapid oral absorption, where it targets and destroys anaerobic bacteria and protozoa through irreversible DNA damage. Because the cytotoxic mechanism is selectively operative only in organisms with anaerobic metabolic pathways, the surrounding healthy aerobic tissues and commensal flora of your animal remain largely unaffected, supporting recovery without widespread disruption of the gut ecosystem.

Broad-Spectrum Antiprotozoal and Antibacterial Coverage in a Single Bolus:
Unlike narrow-spectrum antibiotics that target only bacterial pathogens, Unim Metrolope Bolus simultaneously addresses both anaerobic bacterial infections and protozoal infestations including Trichomonas, Giardia, and Histomonas species, making it a versatile and highly efficient therapeutic choice across a range of mixed-pathogen conditions commonly encountered in livestock. This dual spectrum reduces the need for multiple concurrent antimicrobial interventions and streamlines the treatment regimen for your herd.

Excellent Tissue Penetration Including Reproductive Tract and Peritoneal Cavity:
Metronidazole's high bioavailability and lipophilic character after oral absorption allow it to achieve therapeutic concentrations across a wide range of target tissues, including the uterine wall, peritoneal lining, and soft tissue sites of infection. This makes Unim Metrolope Bolus particularly effective in the management of post-partum metritis, retained placenta complications, and reproductive tract anaerobic infections, which are among the most economically impactful health challenges in dairy and breeding livestock herds.

Convenient Bolus Format for Precise, Stress-Reduced Administration:
The solid bolus format of Unim Metrolope eliminates the dose measurement variability and spill risk inherent in liquid or powder preparations, ensuring that your livestock animal receives the full prescribed dose with each administration. The compact bolus can be delivered rapidly using a standard balling gun, minimizing animal restraint time and handler stress while supporting compliance with multi-day treatment protocols on working farms.

Rapid Absorption and Onset of Therapeutic Action:
Following oral administration, Metronidazole is absorbed efficiently from the ruminant gastrointestinal tract, achieving plasma concentrations sufficient for antimicrobial activity within a clinically meaningful timeframe. Consistent daily administration as prescribed by your veterinarian ensures that plasma levels are maintained at or above minimum inhibitory concentrations for susceptible organisms throughout the treatment course, supporting thorough bacterial and protozoal clearance and reducing the risk of incomplete eradication.

Compatible with Multi-Drug Protocols for Mixed Infections:
Metronidazole's exclusive activity against obligate anaerobes means it is pharmacologically compatible with and clinically complementary to aerobic-spectrum antibiotics such as penicillins, aminoglycosides, and cephalosporins in the management of mixed aerobic-anaerobic infections. Under veterinary guidance, Unim Metrolope Bolus can be incorporated into combination treatment protocols targeting complex infections involving both aerobic and anaerobic pathogen components, reinforcing overall therapeutic efficacy.

How to Use:

Unim Metrolope Bolus must be administered exclusively under the direction and supervision of a registered veterinary physician. The dose, treatment duration, and route of administration will be individually determined by your veterinarian based on the livestock animal's species, body weight, nature of infection, and clinical assessment.

Storage Advice:

Store unopened Unim Metrolope Bolus in a cool, dry place below 25 degrees Celsius, away from direct sunlight, moisture, and heat sources. Do not freeze. Once the strip or container has been opened, reseal securely and use remaining boluses within the period specified on the packaging. Keep out of reach of children and non-target animals at all times. Do not use after the best-before date printed on the strip or outer carton.

About the Brand:

Unim Pharma Lab Pvt. Ltd. was established in 1999 in Himatnagar, Gujarat, India, with a founding commitment to developing trustworthy, high-quality veterinary medicines and feed supplements that address the real-world health challenges of livestock, poultry, aquaculture, equine, and companion animals across domestic and international markets. The company holds ISO 9001:2008, WHO-GMP, and GLP certifications, and manufactures more than 150 veterinary formulations across diverse dosage forms including oral liquids, powders, tablets, boluses, sprays, and herbal products from WHO-GMP-compliant manufacturing facilities, with a distribution presence spanning South America, Asia, Africa, and Europe. Unim Pharma's R&D philosophy centers on developing cost-effective, clinically validated formulations that guarantee quality, safety, and efficacy for practitioners and livestock owners operating at every level of scale, guided by an unwavering commitment to animal ethics and the highest standards of pharmaceutical manufacturing integrity. This dedication to accessible, quality-first animal healthcare aligns with Animeal's commitment to bringing veterinary-grade, evidence-based products to the animals and animal owners who depend on them most. Discover Unim Pharma today.

Disclaimer:

Please note that while Unim Metrolope Bolus is formulated from Metronidazole BP, a clinically validated nitroimidazole antibacterial and antiprotozoal agent, and is appropriate for use in large livestock animals including cattle, buffalo, sheep, and goats under veterinary supervision, it is a prescription-only veterinary pharmaceutical and is not suitable for unsupervised farm use or administration without a valid veterinary prescription. The use of metronidazole in food-producing animals is subject to regulatory restrictions that vary by country and jurisdiction; in certain markets including the United States, extra-label use of nitroimidazoles in food-producing species is prohibited under federal regulations, and livestock owners must confirm compliance with applicable local regulatory requirements with their veterinarian before use. Mandatory meat and milk withdrawal periods must be strictly observed following treatment to prevent residue entry into the food chain. For livestock animals with a history of hepatic or renal impairment, seizure disorders, or known hypersensitivity to nitroimidazoles, consult your veterinarian before introducing this product. Animeal supports your pet's health and happiness journey but does not replace the advice of a qualified veterinary professional.

Q: Which animal species and conditions is Unim Metrolope Bolus suitable for?
Unim Metrolope Bolus is formulated for use in large livestock species including cattle, buffalo, sheep, and goats, and is indicated for a range of anaerobic bacterial and protozoal conditions including metritis, endometritis, post-partum uterine infections, gastrointestinal anaerobic infections, clostridiosis, bovine trichomoniasis, foot rot with anaerobic involvement, and other tissue infections involving obligate anaerobes. It is not recommended for use in pregnant animals, particularly in the first trimester, nor in very young neonatal animals without explicit veterinary direction. Any use must be preceded by veterinary examination and formal prescription.
Q: How often and for how long should Unim Metrolope Bolus be administered?
The frequency and duration of treatment with Unim Metrolope Bolus are determined entirely by the attending veterinarian based on the individual animal's body weight, species, severity of infection, and clinical response. In general veterinary practice, oral metronidazole bolus therapy in large animals is typically administered once daily for five to seven days as a treatment course. For intrauterine applications, the number of boluses and administration frequency will be specifically directed by your veterinarian. Under no circumstances should dosing schedules be self-adjusted without veterinary guidance.
Q: How effective is Unim Metrolope Bolus against anaerobic infections and protozoal disease in livestock?
Metronidazole is recognized by veterinary pharmacologists as one of the most effective agents available against obligate anaerobic bacterial pathogens and susceptible protozoal organisms, with decades of clinical use in both small and large animal medicine confirming its bactericidal potency and broad antiprotozoal spectrum. For uterine infections caused by anaerobic bacteria, intrauterine and systemic metronidazole therapy has been consistently associated with clearance of pathogens including Bacteroides and Fusobacterium species. For protozoal conditions such as trichomoniasis, peer-reviewed research has documented efficacy in reducing organism burden and supporting reproductive recovery. The full therapeutic benefit is contingent on completing the prescribed treatment course and accurate dosing by body weight.
Q: Are there any side effects or safety concerns associated with Unim Metrolope Bolus?
When administered at prescribed doses under veterinary supervision, Metronidazole bolus therapy is generally well tolerated in large livestock animals. Potential adverse effects at standard therapeutic doses are uncommon but may include transient gastrointestinal disturbance. At high doses, neurological signs including ataxia, muscle tremors, and disorientation have been reported in susceptible animals, particularly those with pre-existing hepatic compromise; these resolve upon dose adjustment or discontinuation. Metronidazole should not be used in pregnant animals in the first trimester, in lactating animals where withdrawal requirements cannot be observed, or in animals with known hypersensitivity to nitroimidazoles. Any unexpected adverse signs following administration should be reported to your veterinarian immediately.
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Frequently Asked Questions

Which animal species and conditions is Unim Metrolope Bolus suitable for?

Unim Metrolope Bolus is formulated for use in large livestock species including cattle, buffalo, sheep, and goats, and is indicated for a range of anaerobic bacterial and protozoal conditions including metritis, endometritis, post-partum uterine infections, gastrointestinal anaerobic infections, clostridiosis, bovine trichomoniasis, foot rot with anaerobic involvement, and other tissue infections involving obligate anaerobes. It is not recommended for use in pregnant animals, particularly in the first trimester, nor in very young neonatal animals without explicit veterinary direction. Any use must be preceded by veterinary examination and formal prescription.

How often and for how long should Unim Metrolope Bolus be administered?

The frequency and duration of treatment with Unim Metrolope Bolus are determined entirely by the attending veterinarian based on the individual animal's body weight, species, severity of infection, and clinical response. In general veterinary practice, oral metronidazole bolus therapy in large animals is typically administered once daily for five to seven days as a treatment course. For intrauterine applications, the number of boluses and administration frequency will be specifically directed by your veterinarian. Under no circumstances should dosing schedules be self-adjusted without veterinary guidance.

How effective is Unim Metrolope Bolus against anaerobic infections and protozoal disease in livestock?

Metronidazole is recognized by veterinary pharmacologists as one of the most effective agents available against obligate anaerobic bacterial pathogens and susceptible protozoal organisms, with decades of clinical use in both small and large animal medicine confirming its bactericidal potency and broad antiprotozoal spectrum. For uterine infections caused by anaerobic bacteria, intrauterine and systemic metronidazole therapy has been consistently associated with clearance of pathogens including Bacteroides and Fusobacterium species. For protozoal conditions such as trichomoniasis, peer-reviewed research has documented efficacy in reducing organism burden and supporting reproductive recovery. The full therapeutic benefit is contingent on completing the prescribed treatment course and accurate dosing by body weight.

Are there any side effects or safety concerns associated with Unim Metrolope Bolus?

When administered at prescribed doses under veterinary supervision, Metronidazole bolus therapy is generally well tolerated in large livestock animals. Potential adverse effects at standard therapeutic doses are uncommon but may include transient gastrointestinal disturbance. At high doses, neurological signs including ataxia, muscle tremors, and disorientation have been reported in susceptible animals, particularly those with pre-existing hepatic compromise; these resolve upon dose adjustment or discontinuation. Metronidazole should not be used in pregnant animals in the first trimester, in lactating animals where withdrawal requirements cannot be observed, or in animals with known hypersensitivity to nitroimidazoles. Any unexpected adverse signs following administration should be reported to your veterinarian immediately.
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