PETVOMI - FIX INJ

Selective 5-HT3 Receptor Antagonism Targets the Root Cause of Vomiting: Unlike metoclopramide or maropitant-class antiemetics that act on dopamine or neurokinin-1 receptors, Ondansetron's selective blockade of 5-HT3 serotonergic receptors both centrally at the CTZ and peripherally at vagal GI terminals makes it uniquely effective against the serotonin-mediated vomiting pathways activated by cytotoxic chemotherapy, uraemia, gastroenteritis, and parvoviral infection.

Drug of Choice for Chemotherapy-Induced Emesis: Petvomi-Fix is clinically established as the first-line antiemetic for dogs and cats undergoing cytotoxic chemotherapy protocols where cisplatin, doxorubicin, and cyclophosphamide trigger massive peripheral serotonin release from enterochromaffin cells in the gut wall, overwhelming conventional antiemetics. Ondansetron's direct 5-HT3 blockade suppresses this chemotherapy-induced emetic cascade with unmatched efficacy.

Rapid Onset via IV or IM Administration: Petvomi-Fix achieves therapeutic plasma concentrations within minutes of intravenous administration, providing rapid clinical control of active vomiting essential in emergency presentations involving dehydration, aspiration risk, or post-surgical nausea where immediate antiemetic effect is critical.

Effective Across a Wide Range of Emetic Causes: Beyond chemotherapy, Ondansetron has demonstrated clinical efficacy in managing vomiting associated with parvoviral enteritis, renal failure (uraemic vomiting), vestibular disorders, postoperative nausea, pancreatitis-associated vomiting, and intractable vomiting of undetermined origin in dogs and cats.

Excellent Safety Profile with Minimal Sedation: Ondansetron does not cross the blood-brain barrier significantly at clinical doses and carries no meaningful dopaminergic, anticholinergic, or sedative activity making it one of the safest antiemetics for use in critically ill, haemodynamically compromised, or post-anaesthetic animals where sedation or cardiovascular depression must be avoided.

Convenient Multi-Dose 10ml Vial: The 10ml vial format provides multiple doses per vial allowing efficient use in clinical and hospital settings, enabling dose titration across different patient sizes, and supporting sustained antiemetic management over the course of a hospitalisation period or chemotherapy cycle.

How to Use

Petvomi-Fix Injection must be administered exclusively by or under the direct supervision of a licensed veterinarian. It is indicated for intravenous (IV) or intramuscular (IM) administration. For IV use, administer slowly over a minimum of 2 to 5 minutes rapid IV bolus is not recommended. The vial should be inspected visually before use do not use if the solution is discoloured, cloudy, or contains visible particulates.

Contraindications:

• Do not use in animals with known hypersensitivity or allergy to ondansetron or any other 5-HT3 receptor antagonist.
• Use with caution in animals with pre-existing hepatic impairment ondansetron is extensively metabolised by the liver and plasma clearance may be significantly reduced, increasing the risk of dose-dependent side effects.
• Do not use concurrently with apomorphine in dogs ondansetron antagonises the emetic effect of apomorphine and will render it ineffective if used for induction of vomiting in toxin ingestion cases.
• Use with caution alongside QT-prolonging medications ondansetron has a dose-dependent QT-prolonging effect on cardiac conduction and concurrent use with other QT-prolonging drugs (certain antibiotics, antifungals, or cardiac medications) requires ECG monitoring under veterinary supervision.
• Not recommended as a standalone treatment in cases where vomiting is a protective reflex always treat the underlying cause concurrently.

Storage Advice:

Store Petvomi-Fix Injection vials at room temperature between 20°C and 25°C. Protect from direct light store in original outer carton until point of use. Do not freeze. Once the vial has been broached (opened), use within 28 days and store refrigerated between 2°C and 8°C. Discard any remaining solution if discolouration, cloudiness, or particulates are observed. Keep out of reach of children and non-target animals. Do not use after the expiry date printed on the vial label.

About the Brand Oriheal Lifesciences:

Petvomi-Fix Injection is manufactured by Oriheal Lifesciences, a New Delhi-based veterinary pharmaceutical company dedicated to developing science-backed, clinically reliable medicines and nutraceuticals for companion and large animals across India. With a comprehensive product portfolio spanning pharma medicines, herbal formulations, nutraceuticals, and grooming products all developed with a focus on safety, efficacy, and veterinary clinical relevance Oriheal Lifesciences has established itself as a trusted partner to veterinarians and pet care professionals across the country. Petvomi-Fix reflects Oriheal's commitment to bringing human-grade pharmaceutical quality to companion animal medicine. Animeal is proud to partner with Oriheal Lifesciences to deliver vet-grade injectable antiemetic solutions to India's growing community of companion animal healthcare professionals and pet parents.

Disclaimer

Petvomi-Fix Injection is a prescription-only veterinary medicine intended for use exclusively under the supervision and prescription of a licensed veterinarian. Animeal provides accurate product and clinical information for reference purposes only and does not substitute professional veterinary diagnosis or treatment decisions. Dosage, route of administration, frequency, and clinical suitability must be assessed by a qualified veterinarian based on the individual animal's species, weight, medical history, and concurrent medications. Self-administration of injectable veterinary medicines without veterinary guidance is strongly discouraged and may cause serious harm to your animal.