RAKSHARAB INJ
In Stock
Raksharab is a standout product in our VETERINARY VACCINES category. Manufactured with the highest standards of biological manufacturing precision, quality assurance, and immunogenic potency by Indian Immunologicals Limited a subsidiary of the National Dairy Development Board (NDDB) headquartered in Hyderabad, Telangana Raksharab delivers a proven, potent, and reliably immunogenic anti-rabies vaccination that has protected millions of dogs, cats, and other domestic animals across India and across the world against rabies one of the oldest, most universally feared, and most invariably fatal viral zoonotic diseases known to science. Raksharab contains inactivated rabies virus with a confirmed potency significantly exceeding the minimum 1.0 IU per dose required by international pharmacopoeial standards demonstrated at 7.2 IU per dose in independent NIH potency testing, making it one of the highest-potency veterinary anti-rabies vaccines tested globally. The virus is propagated in the internationally established BHK-21 (Baby Hamster Kidney) cell line a Biosafety Level 2 mammalian cell culture system that provides consistent, reproducible virus yields with defined and controlled biological characteristics and inactivated using an aziridine compound that eliminates viral infectivity completely while preserving the full antigenic integrity of the rabies virus surface glycoproteins responsible for eliciting protective immune responses. In India where rabies remains endemic across virtually all states, where an estimated 20,000 human deaths from rabies occur annually, and where domestic dogs are the primary reservoir and vector of human rabies exposure responsible annual vaccination of every owned dog with a proven, potent anti-rabies vaccine like Raksharab is not merely a veterinary health recommendation it is a fundamental public health obligation. With Raksharab, every veterinarian administering this vaccine is simultaneously protecting their animal patient, the patient's owner and family, and the broader community from the most terrifying of preventable diseases. With Raksharab, you can trust that you are offering every animal patient the very finest in proven, internationally validated, and maximally potent anti-rabies immunological protection.
Composition:
- Inactivated Rabies Virus BHK-21 Cell Line Propagated (Primary Immunogen): the core active immunogenic component of Raksharab live rabies virus of the L.Pasteur 2061 vaccine strain propagated to high titre in BHK-21 (Baby Hamster Kidney) mammalian cell culture, then completely inactivated using an aziridine compound (beta-propiolactone derivative) that alkylates viral nucleic acid, eliminating all residual infectivity and rendering the vaccine incapable of causing rabies infection, while preserving the conformational integrity and immunogenic potency of the rabies virus surface glycoprotein (RVG) the primary target antigen that elicits the virus-neutralising antibody (VNA) response responsible for protective immunity. The BHK-21 cell line provides a consistent, well-characterised biological substrate for high-titre virus propagation with defined passage history and excellent batch-to-batch reproducibility ensuring the consistent antigen quantity and immunogenic quality that is the foundation of reliable vaccination outcomes. Each manufactured batch is independently tested for potency using the NIH (National Institutes of Health) mouse potency challenge test with individual batch potency values significantly exceeding the international minimum requirement of 1.0 IU per dose, ensuring every vial of Raksharab delivers the antigen load required for reliable seroconversion
- Potency > 1.0 IU per dose (Independently Validated at 7.2 IU/dose): the confirmed and independently validated immunogenic potency of Raksharab significantly exceeds the minimum 1.0 IU per dose threshold established by the European Pharmacopoeia, WHO, and international regulatory standards for inactivated rabies vaccines. Independent NIH potency testing conducted by the EU/WOAH/WHO Reference Laboratory for Rabies, ANSES-Nancy, France demonstrated Raksharab's potency at 7.2 IU per dose one of the highest potency values recorded among veterinary anti-rabies vaccines in comparative testing, providing a substantial safety margin above the minimum and ensuring reliable protective seroconversion even in animals with suboptimal immune response at the time of vaccination
- Aluminium Hydroxide Adjuvant: a pharmaceutical-grade, internationally established mineral oil adjuvant that forms a depot of vaccine antigen at the injection site following subcutaneous or intramuscular administration slowly releasing the inactivated rabies virus antigen to the local immune surveillance cells (dendritic cells, macrophages) over an extended period that significantly amplifies and prolongs the adaptive immune response compared to antigen alone. The aluminium hydroxide depot stimulates a stronger, more durable antigen-presenting cell activation, a more robust T-helper cell response, and ultimately a higher, more persistent virus-neutralising antibody titre contributing to the long-lasting protective immunity that makes Raksharab effective for the 1-year and 3-year re-vaccination intervals used in different countries and clinical contexts
- Sterile Phosphate Buffered Saline (Vehicle): a pharmaceutical-grade, isotonic buffered saline vehicle that maintains the pH and osmolality of the vaccine suspension within the physiological range ensuring complete compatibility with subcutaneous and intramuscular tissue, minimal injection site reaction, and full preservation of the adjuvanted antigen suspension's physical stability throughout the vial's shelf life under cold chain storage conditions
