VACCINE
RAKSHARAB INJ
RAKSHARAB INJ
By INDIAN IMMUNOLOGIGALS
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About Product
Raksharab is a standout product in our VETERINARY VACCINES category. Manufactured with the highest standards of biological manufacturing precision, quality assurance, and immunogenic potency by Indian Immunologicals Limited a subsidiary of the National Dairy Development Board (NDDB) headquartered in Hyderabad, Telangana Raksharab delivers a proven, potent, and reliably immunogenic anti-rabies vaccination that has protected millions of dogs, cats, and other domestic animals across India and across the world against rabies one of the oldest, most universally feared, and most invariably fatal viral zoonotic diseases known to science. Raksharab contains inactivated rabies virus with a confirmed potency significantly exceeding the minimum 1.0 IU per dose required by international pharmacopoeial standards demonstrated at 7.2 IU per dose in independent NIH potency testing, making it one of the highest-potency veterinary anti-rabies vaccines tested globally. The virus is propagated in the internationally established BHK-21 (Baby Hamster Kidney) cell line a Biosafety Level 2 mammalian cell culture system that provides consistent, reproducible virus yields with defined and controlled biological characteristics and inactivated using an aziridine compound that eliminates viral infectivity completely while preserving the full antigenic integrity of the rabies virus surface glycoproteins responsible for eliciting protective immune responses. In India where rabies remains endemic across virtually all states, where an estimated 20,000 human deaths from rabies occur annually, and where domestic dogs are the primary reservoir and vector of human rabies exposure responsible annual vaccination of every owned dog with a proven, potent anti-rabies vaccine like Raksharab is not merely a veterinary health recommendation it is a fundamental public health obligation. With Raksharab, every veterinarian administering this vaccine is simultaneously protecting their animal patient, the patient's owner and family, and the broader community from the most terrifying of preventable diseases. With Raksharab, you can trust that you are offering every animal patient the very finest in proven, internationally validated, and maximally potent anti-rabies immunological protection.
Composition:
- Inactivated Rabies Virus BHK-21 Cell Line Propagated (Primary Immunogen): the core active immunogenic component of Raksharab live rabies virus of the L.Pasteur 2061 vaccine strain propagated to high titre in BHK-21 (Baby Hamster Kidney) mammalian cell culture, then completely inactivated using an aziridine compound (beta-propiolactone derivative) that alkylates viral nucleic acid, eliminating all residual infectivity and rendering the vaccine incapable of causing rabies infection, while preserving the conformational integrity and immunogenic potency of the rabies virus surface glycoprotein (RVG) the primary target antigen that elicits the virus-neutralising antibody (VNA) response responsible for protective immunity. The BHK-21 cell line provides a consistent, well-characterised biological substrate for high-titre virus propagation with defined passage history and excellent batch-to-batch reproducibility ensuring the consistent antigen quantity and immunogenic quality that is the foundation of reliable vaccination outcomes. Each manufactured batch is independently tested for potency using the NIH (National Institutes of Health) mouse potency challenge test with individual batch potency values significantly exceeding the international minimum requirement of 1.0 IU per dose, ensuring every vial of Raksharab delivers the antigen load required for reliable seroconversion
- Potency > 1.0 IU per dose (Independently Validated at 7.2 IU/dose): the confirmed and independently validated immunogenic potency of Raksharab significantly exceeds the minimum 1.0 IU per dose threshold established by the European Pharmacopoeia, WHO, and international regulatory standards for inactivated rabies vaccines. Independent NIH potency testing conducted by the EU/WOAH/WHO Reference Laboratory for Rabies, ANSES-Nancy, France demonstrated Raksharab's potency at 7.2 IU per dose one of the highest potency values recorded among veterinary anti-rabies vaccines in comparative testing, providing a substantial safety margin above the minimum and ensuring reliable protective seroconversion even in animals with suboptimal immune response at the time of vaccination
- Aluminium Hydroxide Adjuvant: a pharmaceutical-grade, internationally established mineral oil adjuvant that forms a depot of vaccine antigen at the injection site following subcutaneous or intramuscular administration slowly releasing the inactivated rabies virus antigen to the local immune surveillance cells (dendritic cells, macrophages) over an extended period that significantly amplifies and prolongs the adaptive immune response compared to antigen alone. The aluminium hydroxide depot stimulates a stronger, more durable antigen-presenting cell activation, a more robust T-helper cell response, and ultimately a higher, more persistent virus-neutralising antibody titre contributing to the long-lasting protective immunity that makes Raksharab effective for the 1-year and 3-year re-vaccination intervals used in different countries and clinical contexts
- Sterile Phosphate Buffered Saline (Vehicle): a pharmaceutical-grade, isotonic buffered saline vehicle that maintains the pH and osmolality of the vaccine suspension within the physiological range ensuring complete compatibility with subcutaneous and intramuscular tissue, minimal injection site reaction, and full preservation of the adjuvanted antigen suspension's physical stability throughout the vial's shelf life under cold chain storage conditions
Features and Benefits
India's Most Trusted Anti-Rabies Vaccine 40...
- India's Most Trusted Anti-Rabies Vaccine 40+ Countries Export Record: Raksharab's international export to over 40 countries worldwide including markets with stringent veterinary biological regulatory requirements is the most compelling and objective validation of its manufacturing quality, biological safety, and immunogenic potency. Products exported to regulated markets must meet the importing country's regulatory requirements for veterinary biologicals a standard that confirms Raksharab's quality exceeds Indian domestic requirements and meets global veterinary vaccination standards
- Independently Validated 7.2 IU/dose Potency Among the Highest in Class: independent NIH potency testing at the WHO/WOAH Reference Laboratory for Rabies confirmed Raksharab single-dose potency at 7.2 IU per dose 7.2 times the minimum international requirement and among the highest potency values recorded in comparative testing of globally marketed veterinary anti-rabies vaccines. This exceptional potency provides maximum confidence in reliable protective seroconversion and durable immunity across the full diversity of dogs, cats, and livestock species vaccinated under Indian field conditions
- BHK-21 Cell Line Production Consistent, Defined, High-Quality Antigen: the use of BHK-21 cell line a globally established, rigorously characterised biological substrate for rabies virus propagation ensures batch-to-batch consistency in viral antigen yield, immunogenic quality, and biological safety that primary tissue-derived vaccine production cannot match. Every batch of Raksharab produced from BHK-21 cells has a defined passage history, documented cell bank quality, and consistent virus growth characteristics the foundation of reliable vaccine potency and immunogenicity
- Provides Protective Immunity Against Fatal Rabies Virus Infection: vaccination with Raksharab stimulates the production of rabies virus-neutralising antibodies (VNA) that upon natural exposure to rabies virus in the vaccinated animal rapidly bind to and neutralise the virus before it can establish neurological infection. A VNA titre of ≥0.5 IU/ml is internationally recognised as the threshold of protective immunity Raksharab's high potency ensures reliable seroconversion above this threshold in healthy, immunocompetent dogs and other domestic animals following the recommended vaccination schedule
- Protects Both Animals and Their Human Families Critical Zoonotic Disease Prevention in the Indian context, domestic dog vaccination with Raksharab is simultaneously a veterinary health intervention and a critical public health measure. With dogs responsible for over 95% of human rabies exposure in India and over 20,000 human rabies deaths annually, every dog vaccinated with Raksharab directly reduces the risk of human rabies exposure within that dog's household and community making Raksharab vaccination the most direct, most cost-effective, and most impactful animal-to-human disease transmission prevention intervention available to Indian veterinarians
- Broad Multi-Species Application Dogs, Cats & All Major Domestic Animals Raksharab is indicated and used for anti-rabies vaccination of all major domestic animal species at risk of rabies exposure in India including dogs (the primary target), cats, cattle, buffaloes, horses, sheep, and goats with a single standardised 1ml dose used across all target species, simplifying vaccine inventory management for veterinary clinics and animal health programme operators
- Both Prophylactic Pre-Exposure and Post-Exposure (Post-Bite) Applications: Raksharab is indicated for both routine prophylactic pre-exposure vaccination to establish and maintain protective immunity in unbitten healthy animals, and as a component of post-bite rabies exposure management protocols in animals that have been bitten or otherwise exposed to a potentially rabid animal when administered promptly as part of a complete post-exposure veterinary protocol
- Convenient Single-Dose Vial Format for Clinic Use: the 1ml single-dose vial eliminates the wastage, contamination risk, and potency degradation concerns associated with multi-dose vials in clinic settings where daily vaccination volumes may be low ensuring every dose administered from a single-dose Raksharab vial is a freshly opened, full-potency, sterile product with no risk of inter-patient contamination from repeated needle entry
Usage and Applications
How to Administer:For administration by a licen...
How to Administer:
For administration by a licensed veterinarian only using strict aseptic technique. Allow the vaccine to reach room temperature before administration do not administer cold vaccine directly from the refrigerator. Gently agitate the vial to ensure uniform resuspension of any settled adjuvant before drawing the dose. Draw 1ml into a sterile, single-use syringe using a fresh, sterile needle. Administer by subcutaneous or intramuscular injection into an appropriate site the lateral neck or interscapular region is most commonly used in dogs and cats. Use a fresh needle for every animal. Do not re-enter the vial with a used needle single-dose vials are for single use only. Observe the animal for 15 to 30 minutes post-vaccination for any acute anaphylactic reaction.
Critical Cold Chain Note: Raksharab must be maintained at +2°C to +8°C throughout storage and transport. Any break in the cold chain including brief exposure to temperatures above 8°C or freezing may compromise vaccine potency and immunogenicity without any visible change in the product's appearance. Always verify cold chain integrity before administration.
About the Brand:
Indian Immunologicals Limited (IIL) is one of India's most prestigious, nationally significant, and internationally respected biologicals companies established as a not-for-profit company under the aegis of the National Dairy Development Board (NDDB) and headquartered in Hyderabad, Telangana. With over four decades of dedicated excellence in the research, development, and manufacture of human and veterinary vaccines and biologicals, IIL has built an unparalleled reputation for scientific rigour, biological manufacturing quality, and genuine public health impact across India and in over 40 countries worldwide. Their veterinary biologicals portfolio anchored by Raksharab as India's leading anti-rabies vaccine reflects IIL's founding mission of advancing animal health, human health, and rural livelihood security through accessible, high-quality, proven biological products. IIL's manufacturing facilities are certified to WHO-GMP standards with international quality assurance systems that meet the stringent regulatory requirements of their global export markets. Their unwavering commitment to scientific excellence, biological quality, and genuine disease prevention impact aligns perfectly with Animeal's mission to provide registered veterinary professionals across India with reliable access to India's most trusted and internationally validated veterinary vaccines and biologicals.
Disclaimer:
Raksharab Anti-Rabies Vaccine is a prescription-only veterinary biological product that must be prescribed, cold-chain-stored, and administered exclusively by or under the direct supervision of a licensed veterinarian using strict aseptic technique. Vaccination should only be performed in clinically healthy animals animals that are ill, nutritionally deficient, parasitically infested, or receiving immunosuppressive medications (including corticosteroids) may have a suboptimal immune response to vaccination and should be evaluated by a veterinarian before any vaccination procedure. The vaccine does not provide immediate protection animals should be considered unprotected for a minimum of 28 days following primary vaccination while the adaptive immune response develops to protective antibody titres. Raksharab is not for human use. In the event of any accidental human exposure to this veterinary biological product, contact a physician immediately. Animeal facilitates enquiry and procurement for registered veterinary professionals and licensed animal health programme operators this product requires cold chain management and must be procured through channels that can guarantee cold chain integrity from storage to delivery.