Skip to content
WOUND AND PAIN RELIEF
TOLFIKIND-MR BOLUS
TOLFIKIND-MR BOLUS
By VET MANKIND
Best deal on the Internet
Prescription Required
Couldn't load pickup availability
Check Availability
Rapid 3-4 Day Delivery,Tiny Extra Fee!
-
Pet Safe
-
Best Quality
-
Fast Delivery
-
Secure Payment
Collapsible content
About Product
Tolfikind MR Bolus by Veticura Mankind, the premium clinical veterinary division of Mankind Pharma Limited, is a revolutionary, first-of-its-kind oral bolus formulation that brings together three pharmacologically complementary active ingredients, namely Tolfenamic Acid, Paracetamol, and Chlorzoxazone, in a single, convenient bolus for large animal use. This triple-action combination addresses one of the most complex and clinically challenging pain scenarios in livestock medicine: the simultaneous presentation of acute inflammation, systemic fever, and painful skeletal muscle spasm that accompanies conditions such as acute mastitis, bovine respiratory disease, metritis, foot rot, musculoskeletal injury, and the postoperative and peri-parturient period. Single-active NSAID boluses traditionally manage only the inflammatory and pyrexic components of pain, leaving muscle tension and spasm, which significantly compound animal distress and impede recovery, unaddressed. Tolfikind MR Bolus closes this therapeutic gap definitively, delivering complete multi-modal pain relief from a single oral dose under veterinary prescription. It is classified as a Schedule H prescription veterinary pharmaceutical and must be administered under the supervision of a registered veterinary practitioner. Animeal is proud to offer Tolfikind MR Bolus as part of its curated range of advanced prescription veterinary medicines for the health, productivity, and welfare of your livestock
Ingredients:
Tolfenamic Acid (Fenemate Class NSAID): Tolfenamic acid is a potent, veterinary-approved non-steroidal anti-inflammatory drug of the fenemate class, closely structurally related to flunixin meglumine and widely used across the European Union and India for pain, fever, and inflammation management in cattle, pigs, dogs, and cats. Its primary mechanism of action operates through balanced, non-selective inhibition of both the COX-1 and COX-2 cyclooxygenase enzyme isoforms. These enzymes are responsible for converting arachidonic acid into the pro-inflammatory prostaglandin cascade, specifically PGE2, PGI2, and thromboxane A2, which are the key molecular mediators that sensitise peripheral nociceptors to pain stimuli, sustain vasodilation and oedema at the site of tissue injury, and activate the hypothalamic thermostat to maintain elevated body temperature during fever. By competitively inhibiting both COX isoforms, tolfenamic acid rapidly reduces prostaglandin synthesis at the tissue level, alleviating the cardinal signs of inflammation including heat, redness, swelling, and pain, while simultaneously normalising body temperature through the hypothalamic pathway. Tolfenamic acid is especially well-established in the treatment of respiratory disease in cattle, acute mastitis as adjunct therapy alongside antibiotics, and musculoskeletal disorders, and its pharmacological profile as a balanced COX inhibitor offers both anti-inflammatory potency and a well-characterised safety margin when used at recommended doses.
Paracetamol (Acetaminophen, Phenylacetic Acid Class): Paracetamol complements the anti-inflammatory action of tolfenamic acid by providing a distinct and additive analgesic and antipyretic mechanism that operates primarily through central nervous system pathways. Unlike NSAIDs, paracetamol's analgesic effect involves the inhibition of prostaglandin synthesis specifically within the central nervous system, modulation of the endocannabinoid system through the AM404 metabolite, and enhancement of descending serotonergic pain-inhibitory pathways in the spinal cord. At the thermoregulatory level, paracetamol reduces hypothalamic prostaglandin signalling, reinforcing the antipyretic action already initiated by tolfenamic acid and providing faster and more complete normalisation of elevated core body temperature. The pharmacokinetic profile of paracetamol, with its rapid gastrointestinal absorption and relatively short half-life, complements the sustained anti-inflammatory action of tolfenamic acid, providing immediate analgesic relief in the early post-dosing period while the NSAID component establishes its full therapeutic tissue concentration. This dual-mechanism analgesic synergy delivers a more comprehensive pain relief experience than either compound alone.
Chlorzoxazone (Benzoxazolone Derivative, Centrally Acting Muscle Relaxant): Chlorzoxazone is a centrally acting benzoxazolone-class muscle relaxant that represents the defining innovation in the Tolfikind MR formulation, distinguishing it from all single-NSAID or NSAID-paracetamol combination boluses available in the Indian market. Its mechanism of action involves modulation of GABA-A and GABA-B receptors in the spinal cord and supraspinal regions, inhibiting multisynaptic reflexes that drive sustained skeletal muscle hypertonicity and painful spasm following musculoskeletal injury, inflammation, or neurological sensitisation. By depressing the exaggerated reflex arcs that sustain muscle tension around inflamed or injured tissue, chlorzoxazone reduces the secondary mechanical pain and movement restriction that accompanies primary inflammatory pain, allowing the animal to ambulate, feed, and rest more normally during the recovery period. This muscle relaxant action is particularly therapeutically valuable in conditions such as foot rot with associated limb musculature guarding, respiratory disease with intercostal and diaphragmatic splinting, and post-calving or post-surgical musculoskeletal strain, where reflex muscle spasm significantly amplifies clinical pain scores and delays return to productive function. Chlorzoxazone is notably well-established in its long-standing use as a combination partner to paracetamol, with this pairing providing synergistic pain relief with improved tolerability in clinical settings.
Features and Benefits
India's First Triple-Action Pain Relief Bol...
India's First Triple-Action Pain Relief Bolus for Livestock: Tolfikind MR is the first bolus formulation in India to combine Tolfenamic Acid, Paracetamol, and Chlorzoxazone in a single oral dose, delivering a multi-modal pharmacological strategy that simultaneously targets peripheral inflammation, central pain signalling, hypothalamic fever, and spinal cord-mediated muscle spasm. This comprehensive approach restores comfort and function far more effectively than single-active pain management protocols.
Synergistic COX Inhibition Plus Central Analgesia for Superior Pain Control: The combination of tolfenamic acid's peripheral COX-1/COX-2 inhibition with paracetamol's central prostaglandin and serotonergic modulation creates an additive analgesic effect that addresses pain through two distinct neurochemical pathways simultaneously. This dual-mechanism action translates to faster onset of noticeable relief and a more sustained reduction in clinical pain scores across the full treatment period.
Unique Chlorzoxazone Advantage for Faster Functional Recovery: By incorporating chlorzoxazone as a centrally acting skeletal muscle relaxant, Tolfikind MR directly targets the reflex muscle guarding and spasm that prolongs suffering and impairs mobility in livestock with musculoskeletal or post-inflammatory conditions. Animals treated with Tolfikind MR return to normal locomotion, feeding behaviour, and productive activity more rapidly than those managed on NSAID-only protocols alone.
Comprehensive Fever Reduction Through Dual Antipyretic Pathways: Both tolfenamic acid and paracetamol independently suppress hypothalamic prostaglandin synthesis and thermoregulatory set-point elevation, working in concert to achieve faster and more complete normalisation of body temperature in febrile animals. This accelerated defervescence reduces the metabolic burden of sustained fever on the animal's cardiovascular, immune, and reproductive systems, supporting broader systemic recovery.
Broad Clinical Applicability Across Livestock's Most Common Conditions: From mastitis and respiratory disease to foot rot and post-surgical recovery, the conditions for which Tolfikind MR is clinically indicated represent some of the most economically significant disease presentations in Indian dairy and livestock farming. A single bolus formulation capable of managing pain, inflammation, fever, and muscle spasm across all these conditions simplifies herd treatment protocols and reduces the number of separate medicines required on the farm.
Manufactured Under the Veticura Mankind Clinical Veterinary Platform: Veticura Mankind is Mankind Pharma's premium clinical veterinary division, dedicated to precision pharmacological solutions for complex animal health conditions requiring veterinary supervision. Manufactured under Mankind Pharma's stringent quality standards and distributed as a Schedule H prescription medicine, Tolfikind MR carries the credibility and clinical assurance of India's fourth largest pharmaceutical company by domestic sales.
Usage and Applications
How to Use:Tolfikind MR Bolus is a Schedule H p...
How to Use:
Tolfikind MR Bolus is a Schedule H prescription veterinary pharmaceutical and must be administered exclusively by or under the direct supervision and prescription of a registered veterinary practitioner. It is not to be dispensed, purchased, or administered without a valid veterinary prescription. The bolus is intended for oral administration in cattle, buffalo, and other large animals. The attending veterinarian will calculate the appropriate dose based on the animal's body weight, the specific condition being treated, and concurrent medications. The bolus should be placed at the back of the animal's mouth using an appropriate balling gun or bolus applicator to ensure complete swallowing without regurgitation. Allow the animal access to water before and after administration. Do not crush or break the bolus unless specifically directed by the attending veterinarian. The full prescribed course must be completed for optimal therapeutic outcome. Do not administer concurrently with other NSAIDs, corticosteroids, or ulcerogenic drugs without veterinary oversight. If any signs of adverse reaction are observed during treatment, discontinue immediately and consult the attending veterinarian.
Storage Advice:
Store unopened Tolfikind MR Bolus in a cool, dry place below 30 degrees Celsius, away from direct sunlight, heat, and moisture. Do not freeze. Keep the pack sealed until the time of use. Store securely in a clinical or veterinary facility, inaccessible to unauthorised individuals and children. Do not use after the best-before date printed on the packaging. Dispose of unused or expired boluses in accordance with applicable veterinary pharmaceutical waste guidelines.
About the Brand:
Mankind Pharma Limited is an Indian multinational pharmaceutical company incorporated in 1991, with active operations beginning in 1995 under the founding vision of Ramesh C. Juneja and Rajeev Juneja, who built the company from a seed capital of Rs 50 lakhs into India's fourth largest pharmaceutical company by domestic sales, with a reported revenue exceeding Rs 450 crore in the veterinary pharmaceutical sector alone. The company operates 25 manufacturing facilities and 6 R&D centres across India and has established itself as the most prescribed pharmaceutical company in the country across multiple therapeutic categories. Veticura Mankind is the advanced clinical veterinary division of Mankind Pharma, designed to deliver cutting-edge pharmaceutical solutions for complex animal health conditions requiring veterinary supervision, with a product philosophy centred on performance, precision, and animal safety. Mankind Pharma's commitment to making high-quality medicines accessible and affordable across India, combined with Veticura's focus on clinically validated, innovation-driven veterinary solutions, aligns with Animeal's commitment to offering only the most trusted, evidence-based prescription veterinary products to the practitioners and livestock keepers we serve. Discover Veticura Mankind today.
Disclaimer:
Please note that Tolfikind MR Bolus contains Tolfenamic Acid, Paracetamol, and Chlorzoxazone and is a Schedule H prescription-only veterinary pharmaceutical for use in large animals including cattle and buffalo. It may only be dispensed, administered, or prescribed by a licensed, registered veterinary practitioner. It is not available for purchase or use without a valid veterinary prescription. This product is not intended for use as a standalone treatment and should be used as part of a comprehensive veterinary management plan that includes appropriate diagnosis, antibacterial therapy where indicated, and supportive care. Tolfikind MR should not be administered concurrently with other NSAIDs, corticosteroids, diuretics such as furosemide, or ACE inhibitors without veterinary supervision, as drug interactions may potentiate adverse effects. Do not administer to animals with a known history of gastrointestinal ulceration, hepatic disease, severe renal impairment, or hypersensitivity to any of the active components. Use during pregnancy should be carefully evaluated by the attending veterinarian, with particular caution in the last trimester. Observe appropriate meat and milk withdrawal periods as specified by the attending veterinarian and as indicated on the product label. Animeal supports your livestock's health and productivity journey but does not replace the advice of a qualified veterinary professional.
