TRAVATAN EYE DROP
Out of Stock
Travatan 40mcg/ml Eye Drops Solution 2.5ml, manufactured by Alcon Inc., is a prescription-grade sterile ophthalmic solution containing Travoprost at a concentration of 40 micrograms per millilitre as its active pharmaceutical ingredient. Belonging to the prostaglandin analogue class of intraocular pressure-lowering agents, Travatan targets the root haemodynamic mechanism of elevated intraocular pressure by enhancing the outflow of aqueous humour from the eye through the uveoscleral pathway, delivering clinically significant and sustained reductions in intraocular pressure (IOP) with a single evening drop per day. Elevated intraocular pressure is the primary modifiable risk factor for glaucoma, a progressive optic neuropathy that is among the leading causes of irreversible blindness in both humans and companion animals. In veterinary medicine, Travoprost ophthalmic solution is used off-label under specialist prescription primarily in dogs diagnosed with primary or secondary open-angle glaucoma and ocular hypertension, where it has demonstrated meaningful IOP-lowering efficacy through the uveoscleral outflow pathway. Travatan's FDA-approved formulation contains Polyquaternium-1 (POLYQUAD) as a preservative, offering a gentler ocular surface profile compared to benzalkonium chloride-preserved alternatives. Animeal is proud to offer Travatan 40mcg/ml Eye Drops Solution 2.5ml as part of its curated veterinary ophthalmology prescription catalogue, supporting veterinary specialists and animal owners in delivering cutting-edge, evidence-based ocular care to their canine companions.
Ingredients:
Travoprost:Travoprost is a synthetic fluorinated prostaglandin F2 alpha (PGF2 alpha) analogue and a highly selective, full agonist at the FP prostanoid receptor subtype. It is formulated as a prodrug in the ester form, which is biologically inactive until hydrolyzed by corneal esterase enzymes following topical ocular instillation. Upon penetration through the corneal epithelium, travoprost is rapidly converted by these esterases to its pharmacologically active free acid form, travoprost free acid, which then binds with high affinity to FP receptors located in the ciliary body and trabecular meshwork.
Polyquaternium-1 (POLYQUAD) 10 micrograms/ml:Polyquaternium-1 is a polymeric quaternary ammonium compound used as the ophthalmic preservative in this formulation. Unlike benzalkonium chloride, which exerts membrane-disrupting toxicity to corneal epithelial cells and disrupts the tear film, Polyquaternium-1 functions as a large polymeric molecule that is too large to penetrate corneal epithelial cells, providing antimicrobial preservation while minimizing cytotoxicity to the ocular surface. This results in a superior corneal tolerability profile, making Travatan with POLYQUAD a preferred option for animals requiring prolonged ophthalmic therapy.
Propylene Glycol (7.5 mg/ml): Propylene glycol serves as a tonicity-adjusting co-solvent and humectant in the formulation, contributing to the isotonicity and physical stability of the solution and supporting comfortable instillation on the ocular surface.
Polyoxyethylene Hydrogenated Castor Oil 40 (HCO-40) 2 mg/ml: This non-ionic surfactant acts as a solubilizer for travoprost, which is inherently poorly water-soluble in its free acid form, ensuring uniform drug distribution throughout the aqueous solution and consistent dose delivery with each drop.
