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INJECTABLE
TRINEUROSOL HP INJ
TRINEUROSOL HP INJ
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About Product
Trineurosol-HP Injection is a standout product in our VETERINARY VITAMIN INJECTABLE category. Crafted with utmost pharmaceutical precision by Tridoss Laboratories Pvt. Ltd. a trusted Indian pharmaceutical manufacturer this injectable delivers Hydroxocobalamin, the most biologically superior and clinically preferred form of parenteral Vitamin B12, directly into the systemic circulation via intramuscular or subcutaneous injection bypassing the gastrointestinal absorption pathway that is frequently impaired in the very animals that need B12 supplementation most. Unlike Cyanocobalamin the cheaper and more commonly used synthetic B12 form Hydroxocobalamin is the naturally occurring, biologically active cobalamin that binds directly to plasma proteins for superior tissue retention, has a significantly longer plasma half-life that reduces injection frequency requirements, and does not require hepatic conversion before becoming biologically active. For animals with pancreatic exocrine insufficiency, chronic intestinal malabsorption, inflammatory bowel disease, or severe dietary B12 deficiency conditions where oral B12 supplementation is completely ineffective parenteral Hydroxocobalamin injection is the only reliable therapeutic option for achieving and maintaining adequate tissue B12 levels. With Trineurosol-HP, you can trust that you are offering every animal patient the very best in pharmaceutical-grade, biologically superior parenteral B12 repletion.
Composition:
Each 1ml ampoule of Trineurosol-HP Injection contains a precisely formulated, pharmaceutical-grade composition for reliable parenteral delivery:
- Hydroxocobalamin 1000mcg/ml (Active Ingredient): the naturally occurring, biologically active form of Vitamin B12 distinguished from the synthetic Cyanocobalamin form by its superior pharmacokinetic profile in three clinically important ways. First, Hydroxocobalamin binds avidly to transcobalamin transport proteins in plasma, achieving significantly higher and more sustained tissue B12 concentrations than Cyanocobalamin following injection. Second, its longer plasma half-life means effective therapeutic B12 tissue concentrations are maintained for significantly longer periods between injections reducing treatment frequency requirements and improving practical compliance in clinical practice. Third, unlike Cyanocobalamin which must first be converted to Hydroxocobalamin or Methylcobalamin by hepatic metabolism before becoming biologically active, Hydroxocobalamin enters the active coenzyme pool directly delivering faster, more complete, and more reliable therapeutic action in the two critical B12-dependent enzymatic pathways: the methylcobalamin pathway (methionine synthesis, DNA methylation, and folate metabolism) and the adenosylcobalamin pathway (propionate metabolism and the methylmalonyl-CoA to succinyl-CoA conversion essential for neurological myelin sheath maintenance)
- Sodium Chloride IP (Isotonic Vehicle): a pharmaceutical-grade isotonic saline base that maintains the osmolality of the injectable solution within the physiological range ensuring minimal tissue irritation, vascular compatibility, and patient comfort upon intramuscular or subcutaneous injection
- Glacial Acetic Acid / Sodium Acetate (pH Buffer): a pharmaceutical buffer system that maintains the solution pH at the optimal range for Hydroxocobalamin stability and parenteral bioavailability preventing chemical degradation of the active ingredient during storage and ensuring complete solubility and stability at the time of injection
- Water for Injection IP (Sterile Vehicle): sterile, pyrogen-free water meeting Indian Pharmacopoeia standards for parenteral preparations the aqueous base delivering the active ingredient in a completely clear, injectable solution free from particulate matter and microbial contamination
Features and Benefits
Definitive Treatment for Vitamin B12 Deficiency...
Definitive Treatment for Vitamin B12 Deficiency Anaemia: the single most important and clinically validated veterinary application of parenteral Hydroxocobalamin providing rapid, complete, and reliable correction of B12 deficiency megaloblastic and macrocytic anaemia in dogs, cats, and large animals where oral B12 supplementation cannot be reliably absorbed. Haematological response including reticulocytosis, rising haemoglobin, and normalisation of red blood cell morphology is typically observed within the first 5 to 10 days of initiating parenteral B12 therapy
Essential Support for Exocrine Pancreatic Insufficiency (EPI): one of the most clinically important veterinary indications for parenteral B12 in dogs EPI causes profound malabsorption of dietary Vitamin B12 through multiple mechanisms including loss of intrinsic factor secretion, bacterial overgrowth consuming dietary B12, and mucosal malabsorption. Virtually all dogs with EPI have significant B12 deficiency that cannot be corrected by oral supplementation alone, making regular parenteral Hydroxocobalamin injection an essential component of comprehensive EPI management alongside enzyme replacement therapy
Chronic Intestinal Malabsorption & Inflammatory Bowel Disease: cats and dogs with chronic enteropathies, protein-losing enteropathy, severe IBD, and intestinal lymphangiectasia frequently develop clinically significant B12 deficiency due to impaired ileal absorption of the B12-intrinsic factor complex parenteral Hydroxocobalamin bypasses this impaired absorptive pathway entirely, delivering therapeutic B12 directly into the systemic circulation regardless of gastrointestinal absorptive status
Neurological Support & Peripheral Neuropathy Management: Vitamin B12 is the essential cofactor for adenosylcobalamin-dependent enzymes responsible for maintaining the structural and functional integrity of the myelin sheath that insulates peripheral nerve axons. B12 deficiency causes progressive demyelination of peripheral nerves resulting in weakness, ataxia, proprioceptive deficits, and sensory neuropathy parenteral Hydroxocobalamin arrests this neurological deterioration and supports myelin repair and remyelination when initiated before irreversible axonal damage occurs
Recovery Support in Debilitated, Post-Surgical & Chronically Ill Animals: the B-complex metabolic roles of Vitamin B12 in energy metabolism, protein synthesis, and DNA replication make it an important supportive supplement for debilitated, post-surgical, anorexic, and chronically ill animals requiring intensive nutritional rehabilitation supporting faster recovery, improved appetite, and restoration of cellular metabolic function
Supports Appetite Stimulation & Weight Gain: clinical experience consistently demonstrates that B12-deficient animals particularly cats with chronic disease and dogs with EPI show significant improvement in appetite, food intake, and body weight following correction of B12 deficiency with parenteral Hydroxocobalamin, as B12 plays a fundamental role in the hypothalamic regulatory pathways that control appetite and satiety
Superior Plasma Retention & Tissue Saturation vs Cyanocobalamin: the significantly superior plasma protein binding and longer half-life of Hydroxocobalamin compared to Cyanocobalamin means that a single therapeutic injection achieves higher peak tissue B12 concentrations that are maintained for longer delivering more complete tissue B12 saturation and a more durable therapeutic response with fewer injections required to maintain adequate B12 status in deficient patients
Cyanide Antidote Action: a unique additional clinical property of Hydroxocobalamin not shared by other B12 forms the cobalt centre of Hydroxocobalamin has an extremely high binding affinity for cyanide ions, forming the stable, non-toxic cyanocobalamin compound that is safely eliminated in urine. This property has been exploited in emergency medicine for cyanide poisoning antidote therapy a use that veterinarians may encounter in cases of smoke inhalation or toxic plant ingestion in companion animals
Usage and Applications
How to Use:For intramuscular (IM) or subcutaneo...
How to Use:
For intramuscular (IM) or subcutaneous (SC) administration by or under the direct supervision of a licensed veterinarian only. Inspect each ampoule visually before use the solution should be clear, deep red in colour, and free from particulate matter. Do not use if the solution appears cloudy, discoloured, or contains visible particles. Draw the required dose into a sterile syringe using aseptic technique. Administer by deep intramuscular injection into an appropriate injection site or by subcutaneous injection as clinically appropriate. Protect drawn solution from light Hydroxocobalamin is photosensitive and should be administered promptly after drawing into the syringe.
Storage Advice:
Store Trineurosol-HP Injection below 25°C in a cool, dry place. Protect strictly from light Hydroxocobalamin is highly photosensitive and exposure to light causes rapid chemical degradation and loss of potency. Store in the original carton until the point of use. Do not freeze. Keep out of reach of children. Do not use after the expiry date printed on the ampoule label and outer carton. Use immediately after opening do not store opened or partially used ampoules.
About the Brand:
Trineurosol-HP is manufactured by Tridoss Laboratories Pvt. Ltd. a trusted Indian pharmaceutical manufacturer with a strong track record of delivering consistent quality pharmaceutical injectable formulations to healthcare professionals and veterinarians across India. With manufacturing facilities operating under strict GMP quality standards and a commitment to pharmaceutical-grade active ingredient purity and concentration accuracy in every ampoule, Tridoss Laboratories ensures that every dose of Trineurosol-HP delivers the reliable, precisely dosed, biologically superior Hydroxocobalamin that veterinarians and their animal patients depend upon for consistent therapeutic outcomes. Their commitment to accessible, quality-assured pharmaceutical manufacturing aligns perfectly with Animeal's mission to provide registered veterinary professionals across India with reliable procurement access to the full spectrum of veterinary pharmaceutical needs.
Disclaimer:
Trineurosol-HP Injection is a prescription-only injectable medicine that must be prescribed and administered exclusively by or under the direct supervision of a licensed veterinarian. It is not available for self-administration or over-the-counter dispensing. Vitamin B12 deficiency in companion animals is frequently a clinical sign of significant underlying disease including exocrine pancreatic insufficiency, inflammatory bowel disease, intestinal lymphangiectasia, and chronic enteropathy that requires comprehensive veterinary diagnosis and management beyond B12 supplementation alone. Always investigate and address the underlying cause of B12 deficiency in parallel with parenteral B12 repletion therapy. Serum Vitamin B12 measurement before and during therapy is recommended where available to guide therapeutic decision-making and monitor response. Animeal facilitates enquiry and procurement for registered veterinary professionals this product is available for veterinary clinic and hospital procurement only.
