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LIVER CARE
ZENTONIL CHEW TABLET (S)
ZENTONIL CHEW TABLET (S)
By VETOQUINAL
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About Product
Vetoquinol Zentonil Chew is a clinically advanced, palatable hepatic support supplement formulated by Vetoquinol specifically for dogs and cats suffering from liver function impairment, chronic hepatic disease, or conditions that place sustained oxidative burden on liver cells. The liver is the body's primary detoxification organ, responsible for metabolising drugs, processing nutrients, synthesising plasma proteins, and neutralising endogenous and exogenous toxins and when its function is compromised, the consequences ripple across virtually every physiological system in your companion's body. Zentonil Chew targets this problem at its biochemical root, combining the gold-standard veterinary hepatoprotectant S-adenosylmethionine (SAMe) with Silybin complexed with phospholipids from milk thistle, Vitamin E, Boswellia serrata, Curcuma longa, and Apium graveolens a multi-targeted botanical and nutraceutical formula designed to replenish depleted glutathione stores, reinforce hepatocellular regeneration, and reduce hepatic inflammation through complementary, synergistic mechanisms. Crucially, each SAMe particle in Zentonil Chew is individually microencapsulated and enteric-coated prior to incorporation into the chew, ensuring gastric-resistant delivery and maximum bioavailability of this acid-sensitive active. Animeal is proud to offer Vetoquinol Zentonil Chew as part of its premium veterinary hepatology range, bringing the preferred choice of veterinarians worldwide to your canine and feline companion.
Ingredients:
S-Adenosylmethionine (SAMe) 200 mg per chew:
(Stable tosylate salt; microencapsulated, individually enteric-coated)
SAMe is the body's universal methyl donor a naturally occurring compound synthesized endogenously in the hepatocyte from the amino acid methionine and adenosine triphosphate (ATP) via the enzyme methionine adenosyltransferase. In a healthy liver, SAMe is produced in abundance and serves three critical biochemical roles: transmethylation (donating methyl groups to DNA, proteins, phospholipids, and neurotransmitters), transsulfuration (serving as the precursor to cysteine and ultimately glutathione), and aminopropylation (supporting polyamine synthesis essential to cell proliferation and repair). When the liver is diseased or under oxidative stress, hepatic SAMe synthesis collapses a catastrophic consequence because SAMe is the rate-limiting precursor to glutathione (GSH), the cell's most powerful endogenous antioxidant. Depleted GSH leaves hepatocytes defenseless against reactive oxygen species (ROS), accelerating lipid peroxidation, mitochondrial dysfunction, and hepatocellular death. Exogenous supplementation of SAMe directly replenishes the hepatic SAMe pool, restores GSH synthesis, reinforces membrane phospholipid integrity through transmethylation, and has been shown in peer-reviewed veterinary studies to support hepatocellular regeneration. The tosylate salt used in Zentonil is the most stable and bioavailable pharmaceutical-grade form of SAMe, and the individual microencapsulation of each SAMe particle in an enteric coating protects it from gastric acid degradation, ensuring that active SAMe reaches the small intestinal mucosa intact for maximal absorption.
Silybin / Phospholipids Complex 50 mg per chew:
(Silybin 16.5 mg + Phosphatidylcholine 33.5 mg; from Silybum marianum)
Silybin is the most pharmacologically active flavonolignan of silymarin the standardised extract of milk thistle (Silybum marianum) whose hepatoprotective properties have been documented for centuries and validated in contemporary peer-reviewed veterinary and human hepatology literature. At the cellular level, silybin exerts its primary action as a potent free-radical scavenger, neutralising ROS within the hepatocyte, inhibiting lipid peroxidation of hepatocyte membrane phospholipids, and directly suppressing pro-inflammatory cytokine production (including TNF-α). Silybin also inhibits the uptake of hepatotoxic substances into hepatocytes by competing for transport receptor binding sites, reducing the intracellular accumulation of toxins. Critically, in Zentonil's formulation, silybin is complexed with phosphatidylcholine a naturally occurring phospholipid. This complexation dramatically increases the oral bioavailability of silybin by converting it from a poorly lipid-soluble compound into a lipophilic complex that is efficiently absorbed via the intestinal lymphatic pathway. Phosphatidylcholine itself additionally reinforces hepatocyte membrane integrity by replenishing the phospholipid bilayer of damaged liver cell membranes.
Vitamin E (Alpha-Tocopherol):
Vitamin E is a fat-soluble, chain-breaking antioxidant that intercepts and quenches lipid peroxyl radicals within cell membranes halting the cascade of oxidative membrane damage that characterises hepatocellular injury. In the liver, Vitamin E works synergistically with SAMe-derived glutathione and with silybin to provide a multi-tiered antioxidant defence each operating in distinct intracellular compartments to provide overlapping, comprehensive free-radical neutralisation.
Boswellia serrata (Indian Frankincense Resin Extract):
Boswellic acids, the primary bioactive constituents of Boswellia serrata resin, exert potent anti-inflammatory effects in the liver by selectively inhibiting 5-lipoxygenase (5-LOX) the enzyme responsible for leukotriene synthesis and by suppressing Nuclear Factor kappa-B (NF-κB) activation, a central transcription factor driving the expression of pro-inflammatory mediators. In the context of hepatic disease, this targeted anti-inflammatory action alleviates the chronic hepatic inflammation that perpetuates fibrotic progression and further hepatocellular damage, supporting the liver's recovery environment.
Curcuma longa (Turmeric Curcuminoids):
The bioactive polyphenols of Curcuma longa, collectively known as curcuminoids (with curcumin as the principal compound), modulate hepatic inflammation through simultaneous inhibition of NF-κB, reduction of hepatic stellate cell activation (a key driver of hepatic fibrosis), and upregulation of Nrf2 the master transcription factor that triggers the cell's own antioxidant and cytoprotective enzyme expression. Curcuminoids also support bile secretion and biliary function, facilitating the liver's detoxification throughput during recovery phases.
Apium graveolens (Celery Seed Extract):
Apium graveolens seed extract provides phthalides and flavonoids phytochemical compounds with demonstrated hepatoprotective, anti-inflammatory, and diuretic properties. In the hepatic context, these compounds support detoxification enzyme activity in liver cells, reduce oxidative stress markers in hepatic tissue, and support mild diuresis that assists in clearing metabolic waste products during liver recovery, complementing the primary actives' direct hepatoprotective actions.
Features and Benefits
Pharmaceutical-Grade SAMe with Patented Microen...
Pharmaceutical-Grade SAMe with Patented Microencapsulation Technology:
The most critical determinant of SAMe supplement efficacy is bioavailability SAMe is highly labile and is rapidly destroyed by stomach acid in standard formulations. Each SAMe particle in Zentonil Chew is individually microencapsulated and enteric-coated before incorporation into the palatable chew, a patented gastric-resistant delivery system that ensures SAMe reaches the small intestine intact for peak absorption. This delivery technology is what separates Zentonil from generic SAMe supplements and reinforces its standing as the preferred choice of veterinarians in clinical hepatology practice worldwide.
Rapid Restoration of Depleted Glutathione Stores:
The most clinically urgent consequence of hepatic disease is the collapse of glutathione synthesis stripping liver cells of their primary defence against oxidative injury and toxin accumulation. Zentonil's SAMe directly restores the hepatic SAMe pool, reinvigorating the transsulfuration pathway and restoring GSH synthesis to protective levels, actively decelerating the oxidative cascade that drives further hepatocellular death. This glutathione-replenishing action is the biochemical cornerstone of Zentonil's hepatoprotective efficacy.
Multi-Botanical, Multi-Mechanism Hepatic Protection:
Unlike single-ingredient hepatic supplements, Zentonil Chew combines five distinct active agents SAMe, silybin-phospholipid complex, Vitamin E, Boswellia serrata, and Curcuma longa that target hepatic disease through different, complementary molecular pathways simultaneously. This multi-targeted approach addresses free-radical scavenging, membrane phospholipid repair, 5-LOX and NF-κB-mediated inflammatory suppression, and Nrf2-pathway cytoprotection in a single, convenient daily chew, delivering a breadth of hepatic support that no single-ingredient product can match.
Enhanced Silybin Bioavailability Through Phospholipid Complexation:
Plain silybin has poor oral bioavailability due to its low lipid solubility. Vetoquinol's formulation incorporates silybin pre-complexed with phosphatidylcholine a technology that dramatically amplifies intestinal absorption of this clinically important hepatoprotectant by enabling lymphatic uptake. This means your canine or feline companion receives measurably more active silybin per dose compared to standard milk thistle or silymarin products, translating the well-established hepatoprotective pharmacology of this botanical into real-world clinical benefit.
Cognitive Support for Senior Pets:
Beyond the liver, SAMe's role as the universal methyl donor in the nervous system makes Zentonil uniquely valuable for senior dogs and cats experiencing age-related cognitive decline. SAMe supports the methylation of monoamine neurotransmitters including dopamine, serotonin, and norepinephrine neurochemicals central to mood, alertness, and cognitive function making this a rare hepatic supplement that simultaneously reinforces neurological health in your ageing companion.
Palatable, Flexible-Administration Chew Format:
Zentonil Chews are palatable and flavoured, eliminating the daily struggle of medicating reluctant or food-selective pets. The chew can be given whole, split in two, crushed and mixed with food, or administered directly by hand all without compromising the integrity of the enteric-coated SAMe particles, which are individually protected at the microparticle level rather than relying on a tablet coating. This flexibility makes compliant, consistent daily dosing straightforward even for the most discerning feline or canine patients.
Usage and Applications
How to Use:Zentonil Chew must be administered u...
How to Use:
Zentonil Chew must be administered under veterinary supervision and following your veterinarian's specific dosage recommendation. The general dosing guideline is one Zentonil 200 mg chew daily per 10 kg of body weight in both dogs and cats, but your veterinarian may adjust this based on your companion's clinical condition, concurrent medications, and biochemical response. For optimal SAMe absorption, Zentonil is ideally administered on an empty stomach at least 30 minutes before a meal. The chew may be given directly by hand, split in half, crushed and mixed into a small quantity of food, or administered whole the enteric-coated microparticles of SAMe will remain protected regardless of the administration method chosen. Do not administer to human patients. Keep out of reach of children. This product is for animal use only and must not be self-prescribed; always use as directed by your veterinarian. If your companion is concurrently receiving medications metabolised by the liver, inform your veterinarian before commencing Zentonil supplementation.
Storage Advice:
Store unopened Vetoquinol Zentonil Chew in a cool, dry place below 25°C, away from direct sunlight and moisture. Do not freeze. Once the pack is opened, ensure the closure is resealed tightly after each use to protect the enteric-coated SAMe particles from humidity and air exposure, which can degrade bioavailability over time. Do not use after the best-before date printed on the packaging.
About the Brand:
Vetoquinol S.A. was founded in 1933 in Lure, north-eastern France, by pharmacist Joseph Frechin, whose pioneering use of oxyquinoline in animal treatment gave birth to one of the world's most enduring and respected veterinary pharmaceutical names. Over nine decades, Vetoquinol has grown from a single-dispensary origin into one of the top ten global veterinary pharmaceutical laboratories, with a direct presence in 24 countries and product distribution across more than 80 nations remaining an independent, family-owned enterprise throughout, a distinction that underpins its unwavering commitment to veterinary science over shareholder expediency. The company's R&D philosophy centres on developing clinically validated, evidence-based veterinary solutions across companion animal and livestock medicine, with a product portfolio spanning pharmaceuticals, nutraceuticals, and dietary supplements rigorously developed and tested to meet the exacting standards of international veterinary practice. Vetoquinol's global presence in the Asia-Pacific region, including India, reflects its mission to make world-class veterinary hepatology support accessible to companion animals and their caregivers wherever they live. This dedication to science, quality, and animal health aligns with Animeal's commitment to offering pet parents products of the highest global standard. Discover Vetoquinol today.
Disclaimer:
Please note that while Vetoquinol Zentonil Chew is formulated from clinically validated nutraceutical actives SAMe, silybin-phospholipid complex, Vitamin E, Boswellia serrata, Curcuma longa, and Apium graveolens and is appropriate for dogs and cats with hepatic health concerns, it is a complementary nutraceutical supplement and is not a replacement for prescribed veterinary therapy, diagnostic investigation, or medical management of underlying hepatic disease. Zentonil Chew should only be administered under the guidance of a licensed veterinarian who has assessed your pet's liver function and confirmed its suitability for your companion's specific clinical presentation. For pets with severe hepatic failure, concurrent use of multiple medications, or known sensitivity to any of the listed botanicals, consult your veterinarian before use. Animeal supports your pet's health and happiness journey but does not replace the advice of a qualified veterinary professional.
