Skip to content
ANTI BIOTIC
COTUM 250MG TABLET
COTUM 250MG TABLET
By MISAE
Best deal on the Internet
Prescription Required
Couldn't load pickup availability
Check Availability
Rapid 3-4 Day Delivery,Tiny Extra Fee!
-
Pet Safe
-
Best Quality
-
Fast Delivery
-
Secure Payment
Collapsible content
About Product
Cotum 250mg Tablet, manufactured by Misae Lifesciences Pvt Ltd, is a prescription-only oral antibiotic tablet containing Cefuroxime Axetil 250mg, a second-generation, semi-synthetic cephalosporin antibiotic formulated to combat a broad range of susceptible bacterial infections affecting multiple organ systems. Bacterial infections in animals, just as in humans, can progress rapidly from localised discomfort to systemic illness when left untreated or when managed with antibiotics of insufficient spectrum. Cotum targets this challenge by delivering Cefuroxime, a bactericidal agent with reliable activity against both Gram-positive and Gram-negative organisms, in a convenient oral tablet format that offers systemic distribution following once or twice-daily dosing under veterinary direction. In veterinary practice, Cefuroxime Axetil is employed under professional supervision for the management of bacterial infections of the respiratory tract, urinary tract, skin and soft tissues, ears, and joints in dogs and cats. Animeal is proud to offer Cotum 250mg Tablet as part of our curated range of prescription pharmaceutical products available to support the health of your canine and feline companions under veterinary guidance.
Ingredients:
Cefuroxime Axetil IP (250mg per tablet): Cefuroxime Axetil (C20H22N4O10S) is an orally active prodrug ester of Cefuroxime, a second-generation cephalosporin antibiotic. As a prodrug, Cefuroxime Axetil itself is pharmacologically inactive. Upon oral administration, it is absorbed across the gastrointestinal mucosa and undergoes rapid hydrolysis by non-specific esterases in the intestinal epithelial cells and plasma, releasing the active moiety Cefuroxime into the systemic circulation. The oral bioavailability of Cefuroxime from Cefuroxime Axetil tablets is approximately 37% on an empty stomach and increases meaningfully to approximately 52% when the tablet is administered with food, making co-administration with a meal the preferred clinical approach. At the molecular level, Cefuroxime exerts its bactericidal action by binding to and irreversibly inhibiting penicillin-binding proteins (PBPs), a family of bacterial transmembrane enzymes, including transpeptidases and carboxypeptidases, that are essential for the final cross-linking steps of peptidoglycan biosynthesis in the bacterial cell wall. Inhibition of PBPs prevents the formation of a structurally sound cell wall, leading to the accumulation of unlinked peptidoglycan precursors, loss of cell wall integrity, osmotic instability, cell lysis, and bacterial death. Because Cefuroxime targets a biosynthetic pathway absent in mammalian cells, it exerts selective toxicity against bacteria while sparing host tissue. Cefuroxime is resistant to hydrolysis by a number of beta-lactamases commonly produced by Gram-negative organisms, which contributes to its broader spectrum of activity compared to first-generation cephalosporins. Its plasma elimination half-life is approximately 1.2 hours in healthy adults, with excretion primarily via renal tubular secretion and glomerular filtration. The antibacterial spectrum includes Staphylococcus aureus (methicillin-sensitive), Streptococcus pyogenes, Streptococcus pneumoniae, Haemophilus influenzae (including beta-lactamase-producing strains), Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, and Moraxella catarrhalis.
Features and Benefits
Broad-Spectrum Bactericidal Activity Against Bo...
Broad-Spectrum Bactericidal Activity Against Both Gram-Positive and Gram-Negative Pathogens:
Cefuroxime's second-generation cephalosporin profile delivers meaningful coverage across both Gram-positive organisms, including Staphylococcus and Streptococcus species responsible for skin and respiratory infections, and Gram-negative bacteria including E. coli, Klebsiella, Proteus, and Haemophilus species commonly implicated in urinary tract and respiratory infections. This dual-spectrum activity makes Cotum 250mg a clinically versatile choice for empiric treatment pending culture and sensitivity results.
Beta-Lactamase Stability for Enhanced Clinical Reliability:
Unlike first-generation cephalosporins, Cefuroxime demonstrates improved stability against hydrolysis by a range of beta-lactamases produced by Gram-negative organisms. This resistance to enzymatic inactivation extends the drug's reliable bactericidal activity against strains that would otherwise inactivate earlier cephalosporins, making Cotum 250mg a more robust choice in mixed or community-acquired bacterial infection settings.
Prodrug Design for Optimal Oral Bioavailability:
The axetil ester prodrug formulation is specifically engineered to overcome the poor oral absorption of the parent Cefuroxime molecule. By leveraging endogenous intestinal esterases for bioactivation, Cefuroxime Axetil achieves substantially superior oral bioavailability compared to free Cefuroxime, delivering therapeutic plasma and tissue concentrations reliably following oral dosing. Food co-administration further enhances this absorption, making the treatment strategy straightforward to implement in clinical practice.
Convenient Oral Administration for Reduced Patient Stress:
Cotum 250mg is administered orally as a tablet, avoiding the patient stress, handling difficulty, and clinical infrastructure requirements associated with injectable antibiotic therapy. For veterinary use, the tablet can be concealed in food or administered directly, making compliance achievable even in patients resistant to handling, and supporting outpatient treatment of uncomplicated bacterial infections without hospitalisation.
Systemic Multi-Organ Distribution for Comprehensive Infection Coverage:
Following absorption, Cefuroxime achieves adequate distribution across multiple body compartments including the lungs, kidneys, skin, soft tissues, and synovial fluid, enabling effective treatment of infections across diverse anatomical sites with a single oral preparation. This broad tissue penetration supports its utility in both localised and disseminated bacterial infections under veterinary management.
Usage and Applications
How to Use:Cotum 250mg Tablet is a prescription...
How to Use:
Cotum 250mg Tablet is a prescription-only medicine and must only be administered under the direct instruction of a registered veterinarian or medical professional. The dose, frequency, and duration of therapy will be determined by the prescribing veterinarian based on the species, body weight, nature and severity of the infection, the susceptibility of the causative organism, and the patient's renal function and overall health status. In animals, Cotum 250mg is administered orally, with or without food, though co-administration with a meal is recommended to maximise absorption and reduce the likelihood of gastrointestinal side effects such as vomiting. The tablet may be concealed in a small amount of food or treat to facilitate administration in reluctant patients. Do not crush, split, or alter the tablet without veterinary guidance. The full prescribed course must be completed even if clinical improvement is observed before its conclusion, as premature discontinuation risks therapeutic failure and the selection of antibiotic-resistant bacterial strains. Do not administer a double dose to compensate for a missed dose; instead, resume the regular schedule at the next prescribed time and consult the veterinarian if doses are frequently missed.
Storage Advice:
Store unopened Cotum 250mg Tablets in a cool, dry place below 25 degrees Celsius, away from direct sunlight, heat, and humidity. Do not freeze. Keep the strip or blister sealed until the time of administration to protect the tablets from moisture and light degradation. Store the product out of reach of children and away from other medications. Do not use after the expiry date printed on the strip or outer carton. Partially used strips should be stored under the same conditions and the remaining tablets used within the validity of the stated expiry date.
About the Brand:
Misae Lifesciences Pvt Ltd was incorporated in November 2022 in Ahmedabad, Gujarat, India, and was founded by a team of healthcare professionals with extensive global experience in pharmaceutical development and commercialisation, operating with the core commitment of delivering quality, safety, and education in healthcare. The company's philosophy centres on responsibility-driven pharmaceutical manufacturing, with a quality assurance culture that originates from its leadership and permeates every aspect of product development and distribution. Misae Lifesciences markets a range of human pharmaceutical formulations spanning antibiotic, anti-inflammatory, musculoskeletal, and supportive therapeutic categories, with products distributed across India through organised pharmacy and healthcare channels. The brand's foundation in global therapeutic expertise and its commitment to value-added healthcare products that serve both the medical fraternity and patients aligns with Animeal's commitment to offering only trusted, professionally validated pharmaceutical products for the health and wellbeing of your beloved companion. Discover Misae Lifesciences today.
Disclaimer:
Please note that while Cotum 250mg Tablet is formulated from Cefuroxime Axetil IP (250mg) and is used in the treatment of susceptible bacterial infections of the respiratory tract, urinary tract, skin, soft tissues, ears, and joints, it is a human-formulated, prescription-only antibiotic medicine and its veterinary use in dogs and cats is under the extra-label direction of a registered veterinarian. This product must not be purchased, stored, or administered to any animal without a valid prescription and explicit instruction from a registered veterinarian. It is not a complete or standalone veterinary medicine and must form part of a broader treatment plan established by the attending veterinarian following clinical examination and, where appropriate, culture and sensitivity testing. For animals with pre-existing kidney disease, hepatic impairment, known allergy to penicillins or cephalosporin antibiotics, diabetes mellitus, or those that are pregnant or lactating, this product must only be used when specifically prescribed by a veterinarian who has assessed the individual patient. Animeal supports your pet's health and happiness journey but does not replace the advice of a qualified veterinary professional.
